L
Ludivine Bochet
Researcher at University of Toulouse
Publications - 6
Citations - 1591
Ludivine Bochet is an academic researcher from University of Toulouse. The author has contributed to research in topics: Cancer & Tumor progression. The author has an hindex of 5, co-authored 6 publications receiving 1302 citations. Previous affiliations of Ludivine Bochet include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion
Béatrice Dirat,Ludivine Bochet,Marta Dabek,Danièle Daviaud,Stéphanie Dauvillier,Bilal Majed,Yuan Yuan Wang,Aline Meulle,Bernard Salles,Sophie Le Gonidec,Ignacio Garrido,Ghislaine Escourrou,Philippe Valet,Catherine Muller +13 more
TL;DR: In vitro and in vivo evidence is provided that invasive cancer cells dramatically impact surrounding adipocytes and peritumoral adipocytes exhibit a modified phenotype and specific biological features sufficient to be named cancer-associated adipocytes (CAA); and CAAs modify the cancer cell characteristics/phenotype leading to a more aggressive behavior.
Journal ArticleDOI
Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer.
Ludivine Bochet,Camille Lehuédé,Stéphanie Dauvillier,Yuan Yuan Wang,Béatrice Dirat,Victor Laurent,Cédric Dray,Romain Guiet,Isabelle Maridonneau-Parini,Sophie Le Gonidec,Bettina Couderc,Ghislaine Escourrou,Philippe Valet,Catherine Muller +13 more
TL;DR: By defining a new stromal cell population, this work confirms the presence of adipocyte-derived fibroblasts (ADF) in breast cancers and offers new opportunities for stroma-targeted therapies in breast cancer.
Journal ArticleDOI
Adipose tissue and breast epithelial cells: a dangerous dynamic duo in breast cancer.
Yuan Yuan Wang,Camille Lehuédé,Camille Lehuédé,Camille Lehuédé,Victor Laurent,Victor Laurent,Béatrice Dirat,Béatrice Dirat,Béatrice Dirat,Stéphanie Dauvillier,Stéphanie Dauvillier,Ludivine Bochet,Ludivine Bochet,Ludivine Bochet,Sophie Le Gonidec,Sophie Le Gonidec,Ghislaine Escourrou,Philippe Valet,Philippe Valet,Catherine Muller,Catherine Muller +20 more
TL;DR: The role that adipose tissue might play by locally affecting breast cancer cell behavior and subsequent clinical consequences arising from this dialog are emphasized, and obesity that was identified as an independent negative prognostic factor in breast cancer is addressed.
Journal ArticleDOI
Cancer-associated adipocytes promotes breast tumor radioresistance.
Ludivine Bochet,Aline Meulle,Aline Meulle,Aline Meulle,Sandrine Imbert,Bernard Salles,Bernard Salles,Philippe Valet,Philippe Valet,Catherine Muller,Catherine Muller +10 more
TL;DR: Light is shed on a new role of tumor-surrounding adipocytes in fostering a radioresistant phenotype in breast tumors, a finding that might have important clinical implications in obese patients that frequently exhibit aggressive diseases.
Book ChapterDOI
Unraveling the obesity and breast cancer links: a role for cancer-associated adipocytes?
TL;DR: It is proposed that a bidirectional crosstalk exists between breast cancer cells and tumor-surrounding adipocytes, and that the tumor-modified adipocytes (or cancer-associated adipocytes) are key actors in tumor progression.