C
Catherine Muller
Researcher at University of Toulouse
Publications - 96
Citations - 6181
Catherine Muller is an academic researcher from University of Toulouse. The author has contributed to research in topics: Adipose tissue & Adipocyte. The author has an hindex of 41, co-authored 90 publications receiving 5233 citations. Previous affiliations of Catherine Muller include Jewish General Hospital & Centre national de la recherche scientifique.
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Journal ArticleDOI
Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion
Béatrice Dirat,Ludivine Bochet,Marta Dabek,Danièle Daviaud,Stéphanie Dauvillier,Bilal Majed,Yuan Yuan Wang,Aline Meulle,Bernard Salles,Sophie Le Gonidec,Ignacio Garrido,Ghislaine Escourrou,Philippe Valet,Catherine Muller +13 more
TL;DR: In vitro and in vivo evidence is provided that invasive cancer cells dramatically impact surrounding adipocytes and peritumoral adipocytes exhibit a modified phenotype and specific biological features sufficient to be named cancer-associated adipocytes (CAA); and CAAs modify the cancer cell characteristics/phenotype leading to a more aggressive behavior.
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Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer.
Ludivine Bochet,Camille Lehuédé,Stéphanie Dauvillier,Yuan Yuan Wang,Béatrice Dirat,Victor Laurent,Cédric Dray,Romain Guiet,Isabelle Maridonneau-Parini,Sophie Le Gonidec,Bettina Couderc,Ghislaine Escourrou,Philippe Valet,Catherine Muller +13 more
TL;DR: By defining a new stromal cell population, this work confirms the presence of adipocyte-derived fibroblasts (ADF) in breast cancers and offers new opportunities for stroma-targeted therapies in breast cancer.
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Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells
Yuan Yuan Wang,Yuan Yuan Wang,Camille Attané,Delphine Milhas,Béatrice Dirat,Stéphanie Dauvillier,Adrien Guerard,Julia Gilhodes,Ikrame Lazar,Nathalie Alet,Victor Laurent,Sophie Le Gonidec,Denis Biard,Caroline Hervé,Frédéric Bost,Guo Sheng Ren,Françoise Bono,Ghislaine Escourrou,Marc Prentki,Laurence Nieto,Philippe Valet,Catherine Muller +21 more
TL;DR: The results show a complex metabolic symbiosis between tumor-surrounding adipocytes and cancer cells that stimulate their invasiveness, highlighting ATGL as a potential therapeutic target to impede breast cancer progression.
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Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer.
Ikrame Lazar,Emily Clement,Stéphanie Dauvillier,Delphine Milhas,Manuelle Ducoux-Petit,Sophie Le-Gonidec,Cedric Moro,Vanessa Soldan,Stéphane Dalle,Stéphanie Balor,Muriel Golzio,Odile Burlet-Schiltz,Philippe Valet,Catherine Muller,Laurence Nieto +14 more
TL;DR: It is shown that adipocytes secrete exosomes in abundance, which are then taken up by tumor cells, leading to increased migration and invasion, and inhibition of this metabolic pathway completely abrogates the exosome-mediated increase in migration.
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Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
Victor Laurent,Victor Laurent,Adrien Guerard,Adrien Guerard,Catherine Mazerolles,Sophie Le Gonidec,Sophie Le Gonidec,Aurélie Toulet,Aurélie Toulet,Laurence Nieto,Laurence Nieto,Falek Zaidi,Bilal Majed,David Garandeau,David Garandeau,Youri Socrier,Muriel Golzio,Muriel Golzio,Thomas Cadoudal,Thomas Cadoudal,Karima Chaoui,Karima Chaoui,Cédric Dray,Cédric Dray,Bernard Monsarrat,Bernard Monsarrat,Odile Schiltz,Odile Schiltz,Yuan Yuan Wang,Yuan Yuan Wang,Bettina Couderc,Philippe Valet,Philippe Valet,Bernard Malavaud,Catherine Muller,Catherine Muller +35 more
TL;DR: It is shown that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity, highlighting the potential benefit of CCR3 antagonists in the treatment of prostate cancers.