L
Luca Busino
Researcher at University of Pennsylvania
Publications - 36
Citations - 3339
Luca Busino is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 17, co-authored 30 publications receiving 2882 citations. Previous affiliations of Luca Busino include Laboratory of Molecular Biology & New York University.
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Journal ArticleDOI
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins
Luca Busino,Florian Bassermann,Alessio Maiolica,Choogon Lee,Patrick M. Nolan,Sofia I. H. Godinho,Giulio Draetta,Michele Pagano +7 more
TL;DR: It is found that both Cry1 and Cry2 proteins are ubiquitinated and degraded via the SCFFbxl3 ubiquitin ligase complex, a prerequisite for the efficient and timely reactivation of Clock-Bmal1 and the consequent expression of Per1 and Per2, two regulators of the circadian clock that display tumor suppressor activity.
Journal ArticleDOI
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period.
Sofia I. H. Godinho,Sofia I. H. Godinho,Sofia I. H. Godinho,Elizabeth S. Maywood,Elizabeth S. Maywood,Elizabeth S. Maywood,Linda Shaw,Linda Shaw,Linda Shaw,Valter Tucci,Valter Tucci,Valter Tucci,Alun R. Barnard,Alun R. Barnard,Alun R. Barnard,Luca Busino,Luca Busino,Luca Busino,Michele Pagano,Michele Pagano,Michele Pagano,Rachel Kendall,Rachel Kendall,Rachel Kendall,Mohamed M. Quwailid,Mohamed M. Quwailid,Mohamed M. Quwailid,M. Rosario Romero,M. Rosario Romero,M. Rosario Romero,John S. O’Neill,John S. O’Neill,John S. O’Neill,Johanna E. Chesham,Johanna E. Chesham,Johanna E. Chesham,Debra Brooker,Debra Brooker,Debra Brooker,Zuzanna Lalanne,Zuzanna Lalanne,Zuzanna Lalanne,Michael H. Hastings,Michael H. Hastings,Michael H. Hastings,Patrick M. Nolan,Patrick M. Nolan,Patrick M. Nolan +47 more
TL;DR: In vivo and in vitro studies reveal a central role for Fbxl3 in mammalian circadian timekeeping and identify a mouse mutation, after hours (Afh), which results in long free-running rhythms of about 27 hours in homozygotes.
Journal ArticleDOI
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
Luca Busino,Maddalena Donzelli,Massimo Chiesa,Daniele Guardavaccaro,Dvora Ganoth,N. Valerio Dorrello,Avram Hershko,Michele Pagano,Giulio Draetta +8 more
TL;DR: The results show that β-TrCP has a crucial role in mediating the response to DNA damage through Cdc25A degradation, and is the F-box protein that targets phosphorylated CDC25A for degradation by the Skp1/Cul1/F-boxprotein complex.
Journal ArticleDOI
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint
Florian Bassermann,David Frescas,Daniele Guardavaccaro,Luca Busino,Angelo Peschiaroli,Michele Pagano,Michele Pagano +6 more
TL;DR: It is shown that, in response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(Cdh1), with the consequent degradation of Plk1, a prominent mitotic kinase.
Journal ArticleDOI
Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo
Daniele Guardavaccaro,Yasusei Kudo,Jérôme Boulaire,Marco Barchi,Luca Busino,Luca Busino,Maddalena Donzelli,Florence Margottin-Goguet,Peter K. Jackson,Lili Yamasaki,Michele Pagano +10 more
TL;DR: Beta-Trcp1 regulates the timely order of meiotic and mitotic events and it is demonstrated that Emi1 is a bona fide substrate of beta-TrCP1.