Showing papers by "Luisa Benussi published in 2020"

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.

Abstract: Summary Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. Methods In this international, retrospective cohort study, we collected data on age at symptom onset, age at death, and disease duration for patients with pathogenic mutations in the GRN and MAPT genes and pathological expansions in the C9orf72 gene through the Frontotemporal Dementia Prevention Initiative and from published papers. We used mixed effects models to explore differences in age at onset, age at death, and disease duration between genetic groups and individual mutations. We also assessed correlations between the age at onset and at death of each individual and the age at onset and at death of their parents and the mean age at onset and at death of their family members. Lastly, we used mixed effects models to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried. Findings Data were available from 3403 individuals from 1492 families: 1433 with C9orf72 expansions (755 families), 1179 with GRN mutations (483 families, 130 different mutations), and 791 with MAPT mutations (254 families, 67 different mutations). Mean age at symptom onset and at death was 49·5 years (SD 10·0; onset) and 58·5 years (11·3; death) in the MAPT group, 58·2 years (9·8; onset) and 65·3 years (10·9; death) in the C9orf72 group, and 61·3 years (8·8; onset) and 68·8 years (9·7; death) in the GRN group. Mean disease duration was 6·4 years (SD 4·9) in the C9orf72 group, 7·1 years (3·9) in the GRN group, and 9·3 years (6·4) in the MAPT group. Individual age at onset and at death was significantly correlated with both parental age at onset and at death and with mean family age at onset and at death in all three groups, with a stronger correlation observed in the MAPT group (r=0·45 between individual and parental age at onset, r=0·63 between individual and mean family age at onset, r=0·58 between individual and parental age at death, and r=0·69 between individual and mean family age at death) than in either the C9orf72 group (r=0·32 individual and parental age at onset, r=0·36 individual and mean family age at onset, r=0·38 individual and parental age at death, and r=0·40 individual and mean family age at death) or the GRN group (r=0·22 individual and parental age at onset, r=0·18 individual and mean family age at onset, r=0·22 individual and parental age at death, and r=0·32 individual and mean family age at death). Modelling showed that the variability in age at onset and at death in the MAPT group was explained partly by the specific mutation (48%, 95% CI 35–62, for age at onset; 61%, 47–73, for age at death), and even more by family membership (66%, 56–75, for age at onset; 74%, 65–82, for age at death). In the GRN group, only 2% (0–10) of the variability of age at onset and 9% (3–21) of that of age of death was explained by the specific mutation, whereas 14% (9–22) of the variability of age at onset and 20% (12–30) of that of age at death was explained by family membership. In the C9orf72 group, family membership explained 17% (11–26) of the variability of age at onset and 19% (12–29) of that of age at death. Interpretation Our study showed that age at symptom onset and at death of people with genetic frontotemporal dementia is influenced by genetic group and, particularly for MAPT mutations, by the specific mutation carried and by family membership. Although estimation of age at onset will be an important factor in future pre-symptomatic therapeutic trials for all three genetic groups, our study suggests that data from other members of the family will be particularly helpful only for individuals with MAPT mutations. Further work in identifying both genetic and environmental factors that modify phenotype in all groups will be important to improve such estimates. Funding UK Medical Research Council, National Institute for Health Research, and Alzheimer's Society.

Performance of the CMS Level-1 trigger in proton-proton collisions at √s = 13 TeV

Abstract: At the start of Run 2 in 2015, the LHC delivered proton-proton collisions at a center-of-mass energy of 13\TeV. During Run 2 (years 2015–2018) the LHC eventually reached a luminosity of 2.1× 1034 cm-2s-1, almost three times that reached during Run 1 (2009–2013) and a factor of two larger than the LHC design value, leading to events with up to a mean of about 50 simultaneous inelastic proton-proton collisions per bunch crossing (pileup). The CMS Level-1 trigger was upgraded prior to 2016 to improve the selection of physics events in the challenging conditions posed by the second run of the LHC. This paper describes the performance of the CMS Level-1 trigger upgrade during the data taking period of 2016–2018. The upgraded trigger implements pattern recognition and boosted decision tree regression techniques for muon reconstruction, includes pileup subtraction for jets and energy sums, and incorporates pileup-dependent isolation requirements for electrons and tau leptons. In addition, the new trigger calculates high-level quantities such as the invariant mass of pairs of reconstructed particles. The upgrade reduces the trigger rate from background processes and improves the trigger efficiency for a wide variety of physics signals.

New insights on the genetic etiology of Alzheimer’s and related dementia

Abstract: Alzheimer’s disease (AD) is a severe and incurable neurodegenerative disease, and the failure to find effective treatments suggests that the underlying pathology remains poorly understood. Due to its strong heritability, deciphering the genetic landscape of AD and related dementia (ADD) is a unique opportunity to advance our knowledge. We completed a meta-analysis of genome-wide association studies (39,106 clinically AD-diagnosed cases, 46,828 proxy-ADD cases and 401,577 controls) with the most promising signals followed-up in 25,392 independent AD cases and 276,086 controls. We report 75 risk loci for ADD, including 42 novel ones. Pathway-enrichment analyses confirm the involvement of amyloid/Tau pathways, highlight the role of microglia and its potential interaction with APP metabolism. Numerous genes exhibited differential expression or splicing in AD-related conditions and gene prioritization implies EGFR signaling and TNF-α pathway through LUBAC complex. We also generated a novel polygenic risk score strongly associated with the risk of future dementia or progression from mild cognitive impairment to dementia. In conclusion, by more than doubling the number of loci associated with ADD risk, our study offers new insights into the pathophysiological processes underlying AD and offers additional therapeutic entry-points and tools for translational genomics.

Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration

Abstract: Objective To assess the diagnostic and prognostic value of serum neurofilament light (NfL) and serum phospho-Tau181 (p-Tau181) in a large cohort of patients with frontotemporal lobar degeneration (FTLD). Methods In this retrospective study, performed on 417 participants, we analysed serum NfL and p-Tau181 concentrations with an ultrasensitive single molecule array (Simoa) approach. We assessed the diagnostic values of serum biomarkers in the differential diagnosis between FTLD, Alzheimer’s disease (AD) and healthy ageing; their role as markers of disease severity assessing the correlation with clinical variables, cross-sectional brain imaging and neurophysiological data; their role as prognostic markers, considering their ability to predict survival probability in FTLD. Results We observed significantly higher levels of serum NfL in patients with FTLD syndromes, compared with healthy controls, and lower levels of p-Tau181 compared with patients with AD. Serum NfL concentrations showed a high accuracy in discriminating between FTLD and healthy controls (area under the curve (AUC): 0.86, p Conclusions The assessment of serum NfL and p-Tau181 may provide a comprehensive view of FTLD, aiding in the differential diagnosis, in staging disease severity and in defining survival probability.

Identification of Heavy, Energetic, Hadronically Decaying Particles Using Machine-Learning Techniques

Abstract: Machine-learning (ML) techniques are explored to identify and classify hadronic decays of highly Lorentz-boosted W/Z/Higgs bosons and top quarks. Techniques without ML have also been evaluated and are included for comparison. The identification performances of a variety of algorithms are characterized in simulated events and directly compared with data. The algorithms are validated using proton-proton collision data at ss = 13TeV, corresponding to an integrated luminosity of 35.9 fb−1. Systematic uncertainties are assessed by comparing the results obtained using simulation and collision data. The new techniques studied in this paper provide significant performance improvements over non-ML techniques, reducing the background rate by up to an order of magnitude at the same signal efficiency.

Search for charged Higgs bosons decaying into a top and a bottom quark in the all-jet final state of pp collisions at √s = 13 TeV

Abstract: A search for charged Higgs bosons (H$^{±}$) decaying into a top and a bottom quark in the all-jet final state is presented. The analysis uses LHC proton-proton collision data recorded with the CMS detector in 2016 at $ \sqrt{s} $ = 13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{−1}$. No significant excess is observed above the expected background. Model-independent upper limits at 95% confidence level are set on the product of the H$^{±}$ production cross section and branching fraction in two scenarios. For production in association with a top quark, limits of 21.3 to 0.007 pb are obtained for H$^{±}$ masses in the range of 0.2 to 3 TeV. Combining this with a search in leptonic final states results in improved limits of 9.25 to 0.005 pb. The complementary s-channel production of an H$^{±}$ is investigated in the mass range of 0.8 to 3 TeV and the corresponding upper limits are 4.5 to 0.023 pb. These results are interpreted using different minimal supersymmetric extensions of the standard model.[graphic not available: see fulltext]

Search for direct top squark pair production in events with one lepton, jets, and missing transverse momentum at 13 TeV with the CMS experiment

Abstract: A search for direct top squark pair production is presented. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV recorded by the CMS experiment at the LHC during 2016, 2017, and 2018, corresponding to an integrated luminosity of 137 fb−1. The search is carried out using events with a single isolated electron or muon, multiple jets, and large transverse momentum imbalance. The observed data are consistent with the expectations from standard model processes. Exclusions are set in the context of simplified top squark pair production models. Depending on the model, exclusion limits at 95% confidence level for top squark masses up to 1.2 TeV are set for a massless lightest supersymmetric particle, assumed to be the neutralino. For models with top squark masses of 1 TeV, neutralino masses up to 600 GeV are excluded.

Pileup mitigation at CMS in 13 TeV data

Abstract: With increasing instantaneous luminosity at the LHC come additional reconstruction challenges. At high luminosity, many collisions occur simultaneously within one proton-proton bunch crossing. The isolation of an interesting collision from the additional "pileup" collisions is needed for effective physics performance. In the CMS Collaboration, several techniques capable of mitigating the impact of these pileup collisions have been developed. Such methods include charged-hadron subtraction, pileup jet identification, isospin-based neutral particle "δβ" correction, and, most recently, pileup per particle identification. This paper surveys the performance of these techniques for jet and missing transverse momentum reconstruction, as well as muon isolation. The analysis makes use of data corresponding to 35.9 fb−1 collected with the CMS experiment in 2016 at a center-of-mass energy of 13 TeV. The performance of each algorithm is discussed for up to 70 simultaneous collisions per bunch crossing. Significant improvements are found in the identification of pileup jets, the jet energy, mass, and angular resolution, missing transverse momentum resolution, and muon isolation when using pileup per particle identification.

Searches for physics beyond the standard model with the MT2 variable in hadronic final states with and without disappearing tracks in proton-proton collisions at s=13Te

Abstract: Two related searches for phenomena beyond the standard model (BSM) are performed using events with hadronic jets and significant transverse momentum imbalance. The results are based on a sample of proton–proton collisions at a center-of-mass energy of $13\,\text {Te}\text {V} $, collected by the CMS experiment at the LHC in 2016–2018 and corresponding to an integrated luminosity of 137$\,\text {fb}^{-1}$. The first search is inclusive, based on signal regions defined by the hadronic energy in the event, the jet multiplicity, the number of jets identified as originating from bottom quarks, and the value of the kinematic variable $M_{\mathrm {T2}}$ for events with at least two jets. For events with exactly one jet, the transverse momentum of the jet is used instead. The second search looks in addition for disappearing tracks produced by BSM long-lived charged particles that decay within the volume of the tracking detector. No excess event yield is observed above the predicted standard model background. This is used to constrain a range of BSM models that predict the following: the pair production of gluinos and squarks in the context of supersymmetry models conserving R-parity, with or without intermediate long-lived charginos produced in the decay chain, the resonant production of a colored scalar state decaying to a massive Dirac fermion and a quark, or the pair production of scalar and vector leptoquarks each decaying to a neutrino and a top, bottom, or light-flavor quark. In most of the cases, the results obtained are the most stringent constraints to date.

Search for a narrow resonance lighter than 200 GeV decaying to a pair of muons in proton-proton collisions at $\sqrt{s}=$ 13 TeV

Abstract: A search is presented for a narrow resonance decaying to a pair of oppositely charged muons using s=13 TeV proton-proton collision data recorded at the LHC. In the 45–75 and 110–200 GeV resonance mass ranges, the search is based on conventional triggering and event reconstruction techniques. In the 11.5–45 GeV mass range, the search uses data collected with dimuon triggers with low transverse momentum thresholds, recorded at high rate by storing a reduced amount of trigger-level information. The data correspond to integrated luminosities of 137 and 96.6 fb-1 for conventional and high-rate triggering, respectively. No significant resonant peaks are observed in the probed mass ranges. The search sets the most stringent constraints to date on a dark photon in the ∼30–75 and 110–200 GeV mass ranges.

Search for physics beyond the standard model in multilepton final states in proton-proton collisions at √{s } = 13 TeV

Abstract: A search for physics beyond the standard model in events with at least three charged leptons (electrons or muons) is presented. The data sample corresponds to an integrated luminosity of 137 fb$^{−1}$ of proton-proton collisions at $ \sqrt{s} $ = 13 TeV, collected with the CMS detector at the LHC in 2016–2018. The two targeted signal processes are pair production of type-III seesaw heavy fermions and production of a light scalar or pseudoscalar boson in association with a pair of top quarks. The heavy fermions may be manifested as an excess of events with large values of leptonic transverse momenta or missing transverse momentum. The light scalars or pseudoscalars may create a localized excess in the dilepton mass spectra. The results exclude heavy fermions of the type-III seesaw model for masses below 880 GeV at 95% confidence level in the scenario of equal branching fractions to each lepton flavor. This is the most restrictive limit on the flavor-democratic scenario of the type-III seesaw model to date. Assuming a Yukawa coupling of unit strength to top quarks, branching fractions of new scalar (pseudoscalar) bosons to dielectrons or dimuons above 0.004 (0.03) and 0.04 (0.03) are excluded at 95% confidence level for masses in the range 15–75 and 108–340 GeV, respectively. These are the first limits in these channels on an extension of the standard model with scalar or pseudoscalar particles.[graphic not available: see fulltext]

Serum Glial Fibrillary Acidic Protein (GFAP) Is a Marker of Disease Severity in Frontotemporal Lobar Degeneration.

Abstract: Background It is still unknown if serum glial fibrillary acidic protein (GFAP) is a useful marker in frontotemporal lobar degeneration (FTLD). Objective To assess the diagnostic and prognostic value of serum GFAP in a large cohort of patients with FTLD. Methods In this retrospective study, performed on 406 participants, we measured serum GFAP concentration with an ultrasensitive Single molecule array (Simoa) method in patients with FTLD, Alzheimer's disease (AD), and in cognitively unimpaired elderly controls. We assessed the role of GFAP as marker of disease severity by analyzing the correlation with clinical variables, neurophysiological data, and cross-sectional brain imaging. Moreover, we evaluated the role of serum GFAP as a prognostic marker of disease survival. Results We observed significantly higher levels of serum GFAP in patients with FTLD syndromes, except progressive supranuclear palsy, compared with healthy controls, but not compared with AD patients. In FTLD, serum GFAP levels correlated with measures of cognitive dysfunction and disease severity, and were associated with indirect measures of GABAergic deficit. Serum GFAP concentration was not a significant predictor of survival. Conclusion Serum GFAP is increased in FTLD, correlates with cognition and GABAergic deficits, and thus shows promise as a biomarker of disease severity in FTLD.

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients.

Abstract: The pathological deposition of the transactive response DNA-binding protein of 43 kDa occurs in the majority (∼97%) of amyotrophic lateral sclerosis and in around 45% of frontotemporal lobar degeneration cases. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration clinically overlap, presenting a continuum of phenotypes. Both amyotrophic lateral sclerosis and frontotemporal lobar degeneration lack treatments capable of interfering with the underlying pathological process and early detection of transactive response DNA-binding protein of 43 kDa pathology would facilitate the development of disease-modifying drugs. The real-time quaking-induced conversion reaction showed the ability to detect prions in several peripheral tissues of patients with different forms of prion and prion-like diseases. Despite transactive response DNA-binding protein of 43 kDa displays prion-like properties, to date the real-time quaking-induced conversion reaction technology has not yet been adapted to this protein. The aim of this study was to adapt the real-time quaking-induced conversion reaction technique for the transactive response DNA-binding protein of 43 kDa substrate and to exploit the intrinsic ability of this technology to amplify minute amount of mis-folded proteins for the detection of pathological transactive response DNA-binding protein of 43 kDa species in the cerebrospinal fluid of amyotrophic lateral sclerosis and frontotemporal lobar degeneration patients. We first optimized the technique with synthetic transactive response DNA-binding protein of 43 kDa-pre-formed aggregates and with autopsy-verified brain homogenate samples and subsequently analysed CSF samples from amyotrophic lateral sclerosis and frontotemporal lobar degeneration patients and controls. Transactive response DNA-binding protein of 43 kDa real-time quaking-induced conversion reaction was able to detect as little as 15 pg of transactive response DNA-binding protein of 43 kDa aggregates, discriminating between a cohort of patients affected by amyotrophic lateral sclerosis and frontotemporal lobar degeneration and age-matched controls with a total sensitivity of 94% and a specificity of 85%. Our data give a proof-of-concept that transactive response DNA-binding protein of 43 kDa is a suitable substrate for the real-time quaking-induced conversion reaction. Transactive response DNA-binding protein of 43 kDa real-time quaking-induced conversion reaction could be an innovative and useful tool for diagnosis and drug development in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The cerebrospinal fluid detection of transactive response DNA-binding protein of 43 kDa pathological aggregates may be exploited as a disease biomarker for amyotrophic lateral sclerosis and frontotemporal lobar degeneration patients.

Search for a heavy Higgs boson decaying to a pair of W bosons in proton-proton collisions at √s = 13 TeV

Abstract: A search for a heavy Higgs boson in the mass range from 0.2 to 3.0 TeV, decaying to a pair of W bosons, is presented. The analysis is based on proton-proton collisions at $ \sqrt{s} $ = 13 TeV recorded by the CMS experiment at the LHC in 2016, corresponding to an integrated luminosity of 35.9 fb$^{−1}$. The W boson pair decays are reconstructed in the 2l2ν and lν2q final states (with l = e or μ). Both gluon fusion and vector boson fusion production of the signal are considered. Interference effects between the signal and background are also taken into account. The observed data are consistent with the standard model (SM) expectation. Combined upper limits at 95% confidence level on the product of the cross section and branching fraction exclude a heavy Higgs boson with SM-like couplings and decays up to 1870 GeV. Exclusion limits are also set in the context of a number of two-Higgs-doublet model formulations, further reducing the allowed parameter space for SM extensions.[graphic not available: see fulltext]

MiRNA Profiling in Plasma Neural-Derived Small Extracellular Vesicles from Patients with Alzheimer's Disease

Abstract: Small extracellular vesicles (EVs) are able to pass from the central nervous system (CNS) into peripheral blood and contain molecule markers of their parental origin. The aim of our study was to isolate and characterize total and neural-derived small EVs (NDEVs) and their micro RNA (miRNA) cargo in Alzheimer's disease (AD) patients. Small NDEVs were isolated from plasma in a population consisting of 40 AD patients and 40 healthy subjects (CTRLs) using high throughput Advanced TaqMan miRNA OpenArrays®, which enables the simultaneous determination of 754 miRNAs. MiR-23a-3p, miR-223-3p, miR-100-3p and miR-190-5p showed a significant dysregulation in small NDEVs from AD patients as compared with controls (1.16 ± 0.49 versus 7.54 ± 2.5, p = 0.026; 9.32 ± 2.27 versus 0.66 ± 0.18, p <0.0001; 0.069 ± 0.01 versus 0.5 ± 0.1, p < 0.0001 and 2.9 ± 1.2 versus 1.93 ± 0.9, p < 0.05, respectively). A further validation analysis confirmed that miR-23a-3p, miR-223-3p and miR-190a-5p levels in small NDEVs from AD patients were significantly upregulated as compared with controls (p = 0.008; p = 0.016; p = 0.003, respectively) whereas miR-100-3p levels were significantly downregulated (p = 0.008). This is the first study that carries out the comparison between total plasma small EV population and NDEVs, demonstrating the presence of a specific AD NDEV miRNA signature.

Measurement of t t ¯ normalised multi-differential cross sections in pp collisions at √s=13TeV , and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Abstract: Normalised multi-differential cross sections for top quark pair ($$\hbox {t}{\bar{\hbox {t}}}$$) production are measured in proton-proton collisions at a centre-of-mass energy of 13$$\,{\text {TeV}}$$ using events containing two oppositely charged leptons. The analysed data were recorded with the CMS detector in 2016 and correspond to an integrated luminosity of $$35.9{\,{\text {fb}}^{-1}} $$. The double-differential $$\hbox {t}{\bar{\hbox {t}}}$$ cross section is measured as a function of the kinematic properties of the top quark and of the $$\hbox {t}{\bar{\hbox {t}}}$$ system at parton level in the full phase space. A triple-differential measurement is performed as a function of the invariant mass and rapidity of the $$\hbox {t}{\bar{\hbox {t}}}$$ system and the multiplicity of additional jets at particle level. The data are compared to predictions of Monte Carlo event generators that complement next-to-leading-order (NLO) quantum chromodynamics (QCD) calculations with parton showers. Together with a fixed-order NLO QCD calculation, the triple-differential measurement is used to extract values of the strong coupling strength $$\alpha _{S}$$ and the top quark pole mass ($$m_{{\text {t}}}^{{\text {pole}}}$$) using several sets of parton distribution functions (PDFs). The measurement of $$m_{{\text {t}}}^{{\text {pole}}}$$ exploits the sensitivity of the $$\hbox {t}{\bar{\hbox {t}}}$$ invariant mass distribution to $$m_{{\text {t}}}^{{\text {pole}}}$$ near the production threshold. Furthermore, a simultaneous fit of the PDFs, $$\alpha _{S}$$, and $$m_{{\text {t}}}^{{\text {pole}}}$$ is performed at NLO, demonstrating that the new data have significant impact on the gluon PDF, and at the same time allow an accurate determination of $$\alpha _{S}$$ and $$m_{{\text {t}}}^{{\text {pole}}}$$. The values $$\alpha _{S}(m_{{\text {Z}}}) = 0.1135{}^{+0.0021}_{-0.0017}$$ and $$m_{{\text {t}}}^{{\text {pole}}} = 170.5 \pm 0.8 \,{\text {GeV}} $$ are extracted, which account for experimental and theoretical uncertainties, the latter being estimated from NLO scale variations. Possible effects from Coulomb and soft-gluon resummation near the $$\hbox {t}{\bar{\hbox {t}}}$$ production threshold are neglected in these parameter extractions. A rough estimate of these effects indicates an expected correction of $$m_{{\text {t}}}^{{\text {pole}}}$$ of the order of $$+1 \,{\text {GeV}} $$, which can be regarded as additional theoretical uncertainty in the current $$m_{{\text {t}}}^{{\text {pole}}}$$ extraction.

Measurement of properties of B(s)(0)s -> mu(+)mu(-) decays and search for B-0 -> mu(+)mu(-) with the CMS experiment

Abstract: Results are reported for the $$ {\mathrm{B}}_{\mathrm{s}}^0 $$→ μ+μ− branching fraction and effective lifetime and from a search for the decay B0→ μ+μ−. The analysis uses a data sample of proton-proton collisions accumulated by the CMS experiment in 2011, 2012, and 2016, with center-of-mass energies (integrated luminosities) of 7 TeV (5 fb−1), 8 TeV (20 fb−1), and 13 TeV (36 fb−1). The branching fractions are determined by measuring event yields relative to B+→ J/ψK+ decays (with J/ψ → μ+μ−), which results in the reduction of many of the systematic uncertainties. The decay $$ {\mathrm{B}}_{\mathrm{s}}^0 $$→ μ+μ− is observed with a significance of 5.6 standard deviations. The branching fraction is measured to be $$ \mathrm{\mathcal{B}}\left({\mathrm{B}}_{\mathrm{s}}^0\to {\upmu}^{+}{\upmu}^{-}\right)=\left[2.9\pm 0.7\left(\exp \right)\pm 0.2\left(\mathrm{frag}\right)\right]\times {10}^{-9} $$, where the first uncertainty combines the experimental statistical and systematic contributions, and the second is due to the uncertainty in the ratio of the $$ {\mathrm{B}}_{\mathrm{s}}^0 $$ and the B+ fragmentation functions. No significant excess is observed for the decay B0→ μ+μ−, and an upper limit of ℬ(B0 → μ+μ−) < 3.6 × 10−10 is obtained at 95% confidence level. The $$ {\mathrm{B}}_{\mathrm{s}}^0 $$→ μ+μ− effective lifetime is measured to be $$ {\tau}_{\upmu^{+}{\upmu}^{-}}={1.70}_{-0.44}^{+0.61} $$ ps. These results are consistent with standard model predictions.

Measurements of $\mathrm{t\bar{t}}$H production and the CP structure of the Yukawa interaction between the Higgs boson and top quark in the diphoton decay channel

Abstract: The first observation of the tt¯H process in a single Higgs boson decay channel with the full reconstruction of the final state (H→γγ) is presented, with a significance of 6.6 standard deviations (σ). The CP structure of Higgs boson couplings to fermions is measured, resulting in an exclusion of the pure CP-odd structure of the top Yukawa coupling at 3.2σ. The measurements are based on a sample of proton-proton collisions at a center-of-mass energy s=13 TeV collected by the CMS detector at the LHC, corresponding to an integrated luminosity of 137 fb-1. The cross section times branching fraction of the tt¯H process is measured to be σtt¯HBγγ=1.56-0.32+0.34 fb, which is compatible with the standard model prediction of 1.13-0.11+0.08 fb. The fractional contribution of the CP-odd component is measured to be fCPHtt=0.00±0.33.

A multi-dimensional search for new heavy resonances decaying to boosted WW, WZ, or ZZ boson pairs in the dijet final state at 13 TeV

Abstract: A search in an all-jet final state for new massive resonances decaying to $$\text{ W }{}{}$$ $$\text{ W }{}{}$$, $$\text{ W }{}{}$$ $$\text{ Z }{}{}$$, or $$\text{ Z }{}{}$$ $$\text{ Z }{}{}$$ boson pairs using a novel analysis method is presented. The analysis is performed on data corresponding to an integrated luminosity of 77.3 $$\,\text {fb}^{-1}$$ recorded with the CMS experiment at the LHC at a centre-of-mass energy of 13 $$\text {Te}\text {V}$$. The search is focussed on potential narrow-width resonances with masses above 1.2 $$\text {Te}\text {V}$$, where the decay products of each $$\text{ W }{}{}$$ or $$\text{ Z }{}{}$$ boson are expected to be collimated into a single, large-radius jet. The signal is extracted using a three-dimensional maximum likelihood fit of the two jet masses and the dijet invariant mass, yielding an improvement in sensitivity of up to 30% relative to previous search methods. No excess is observed above the estimated standard model background. In a heavy vector triplet model, spin-1 $${\text {Z}}^{\prime }$$ and $${\text {W}}^{\prime }$$ resonances with masses below 3.5 and 3.8 $$\text {Te}\text {V}$$, respectively, are excluded at 95% confidence level. In a bulk graviton model, upper limits on cross sections are set between 27 and 0.2 $$\,\text {fb}$$ for resonance masses between 1.2 and 5.2 $$\text {Te}\text {V}$$, respectively. The limits presented in this paper are the best to date in the dijet final state.

Search for a light pseudoscalar Higgs boson in the boosted μμττ final state in proton-proton collisions at √s = 13 TeV

Abstract: A search for a light pseudoscalar Higgs boson (a) decaying from the 125 GeV (or a heavier) scalar Higgs boson (H) is performed using the 2016 LHC proton-proton collision data at $$ \sqrt{s} $$ = 13 TeV, corresponding to an integrated luminosity of 35.9 fb−1, collected by the CMS experiment. The analysis considers gluon fusion and vector boson fusion production of the H, followed by the decay H → aa → μμττ, and considers pseudoscalar masses in the range 3.6 < ma < 21 GeV. Because of the large mass difference between the H and the a bosons and the small masses of the a boson decay products, both the μμ and the ττ pairs have high Lorentz boost and are collimated. The ττ reconstruction efficiency is increased by modifying the standard technique for hadronic τ lepton decay reconstruction to account for a nearby muon. No significant signal is observed. Model-independent limits are set at 95% confidence level, as a function of ma, on the branching fraction (ℬ) for H → aa → μμττ, down to 1.5 (2.0) × 10−4 for mH = 125 (300) GeV. Model-dependent limits on ℬ(H → aa) are set within the context of two Higgs doublets plus singlet models, with the most stringent results obtained for Type-III models. These results extend current LHC searches for heavier a bosons that decay to resolved lepton pairs and provide the first such bounds for an H boson with a mass above 125 GeV.

Search for physics beyond the standard model in events with jets and two same-sign or at least three charged leptons in proton-proton collisions at s=13TeV.

Abstract: A data sample of events from proton-proton collisions with at least two jets, and two isolated same-sign or three or more charged leptons, is studied in a search for signatures of new physics phenomena. The data correspond to an integrated luminosity of 137fb-1 at a center-of-mass energy of 13TeV , collected in 2016-2018 by the CMS experiment at the LHC. The search is performed using a total of 168 signal regions defined using several kinematic variables. The properties of the events are found to be consistent with the expectations from standard model processes. Exclusion limits at 95% confidence level are set on cross sections for the pair production of gluinos or squarks for various decay scenarios in the context of supersymmetric models conserving or violating R parity. The observed lower mass limits are as large as 2.1TeV for gluinos and 0.9TeV for top and bottom squarks. To facilitate reinterpretations, model-independent limits are provided in a set of simplified signal regions.

Search for electroweak production of a vector-like T quark using fully hadronic final states

Abstract: A search is performed for electroweak production of a vector-like top quark partner T of charge 2/3 in association with a top or bottom quark, using proton-proton collision data at $$ \sqrt{s} $$ = 13 TeV collected by the CMS experiment at the LHC in 2016. The data sample corresponds to an integrated luminosity of 35.9 fb−1. The search targets T quarks over a wide range of masses and fractional widths, decaying to a top quark and either a Higgs boson or a Z boson in fully hadronic final states. The search is performed using two experimentally distinct signatures that depend on whether or not each quark from the decays of the top quark, Higgs boson, or Z boson produces an individual resolved jet. Jet substructure, b tagging, and kinematic variables are used to identify the top quark and boson jets, and also to suppress the standard model backgrounds. The data are found to be consistent with the expected backgrounds. Upper limits at 95% confidence level are set on the cross sections for T quark-mediated production of tHQq, tZQq, and their sum, where Q is the associated top or bottom heavy quark and q is another associated quark. The limits are given for each search signature for various T quark widths up to 30% of the T quark mass, and are between 2 pb and 20 fb for T quark masses in the range 0.6–2.6 TeV. These results are significantly more sensitive than prior searches for electroweak single production of T → tH and represent the first constraints on T → tZ using hadronic decays of the Z boson with this production mode.

Search for supersymmetry in pp collisions at √s=13 TeV with 137 fb−1 in final states with a single lepton using the sum of masses of large-radius jets

Abstract: Results are reported from a search for new physics beyond the standard model in proton-proton collisions in final states with a single lepton; multiple jets, including at least one jet tagged as originating from the hadronization of a bottom quark; and large missing transverse momentum. The search uses a sample of proton-proton collision data at s=13 TeV, corresponding to 137 fb-1, recorded by the CMS experiment at the LHC. The signal region is divided into categories characterized by the total number of jets, the number of bottom quark jets, the missing transverse momentum, and the sum of masses of large-radius jets. The observed event yields in the signal regions are consistent with estimates of standard model backgrounds based on event yields in the control regions. The results are interpreted in the context of simplified models of supersymmetry involving gluino pair production in which each gluino decays into a top quark-antiquark pair and a stable, unobserved neutralino, which generates missing transverse momentum in the event. Scenarios with gluino masses up to about 2150 GeV are excluded at 95% confidence level (or more) for neutralino masses up to 700 GeV. The highest excluded neutralino mass is about 1250 GeV, which holds for gluino masses around 1850 GeV.

Search for direct pair production of supersymmetric partners to the τ lepton in proton–proton collisions at √s=13TeV

Abstract: A search is presented for $\tau$ slepton pairs produced in proton-proton collisions at a center-of-mass energy of 13 TeV. The search is carried out in events containing two $\tau$ leptons in the final state, on the assumption that each $\tau$ slepton decays primarily to a $\tau$ lepton and a neutralino. Events are considered in which each $\tau$ lepton decays to one or more hadrons and a neutrino, or in which one of the $\tau$ leptons decays instead to an electron or a muon and two neutrinos. The data, collected with the CMS detector in 2016 and 2017, correspond to an integrated luminosity of 77.2 fb$^{-1}$. The observed data are consistent with the standard model background expectation. The results are used to set 95% confidence level upper limits on the cross section for $\tau$ slepton pair production in various models for $\tau$ slepton masses between 90 and 200 GeV and neutralino masses of 1, 10, and 20 GeV. In the case of purely left-handed $\tau$ slepton production and decay to a $\tau$ lepton and a neutralino with a mass of 1 GeV, the strongest limit is obtained for a $\tau$ slepton mass of 125 GeV at a factor of 1.14 larger than the theoretical cross section.