L
Luka Kulic
Researcher at University of Zurich
Publications - 43
Citations - 1596
Luka Kulic is an academic researcher from University of Zurich. The author has contributed to research in topics: Immune system & Cerebral amyloid angiopathy. The author has an hindex of 21, co-authored 38 publications receiving 1209 citations. Previous affiliations of Luka Kulic include ETH Zurich.
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Journal ArticleDOI
A Practical Guide to Immunoassay Method Validation
Ulf Andreasson,Armand Perret-Liaudet,Linda J C van Waalwijk van Doorn,Kaj Blennow,Davide Chiasserini,Sebastiaan Engelborghs,Tormod Fladby,Sermin Genc,Niels Kruse,H. Bea Kuiperij,Luka Kulic,Piotr Lewczuk,Brit Mollenhauer,Barbara Mroczko,Lucilla Parnetti,Eugeen Vanmechelen,Marcel M. Verbeek,Bengt Winblad,Henrik Zetterberg,Henrik Zetterberg,Marleen J.A. Koel-Simmelink,Charlotte E. Teunissen +21 more
TL;DR: Standard operating procedures (SOPs) with step-by-step instructions for a number of different validation parameters is included in the present work together with a validation report template, which allow for a well-ordered presentation of the results.
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T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer's disease-like cerebral amyloidosis.
Maria Teresa Ferretti,Mario Merlini,Claudia Späni,Christoph Gericke,N. Schweizer,Gaby Enzmann,Britta Engelhardt,Luka Kulic,Tobias Suter,Roger M. Nitsch +9 more
TL;DR: Results indicate that cerebral amyloidosis promotes T- cell infiltration but interferes with local antigen presentation and T-cell activation, suggesting the inability of the brain immune surveillance to orchestrate a protective immune response to amylid-beta peptide might contribute to the accumulation of amyloids in the progression of the disease.
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Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study.
TL;DR: The data support the notion of T-cell occurrence in AD brains and suggest that, in advanced stages of AD, T- cell extravasation is driven by tau-related neurodegenerative changes rather than by cerebral amyloidosis.
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S-Adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease
Michael Linnebank,Julius Popp,Yvo M. Smulders,Desirée E.C. Smith,Alexander Semmler,Melinda Farkas,Luka Kulic,Gabriela Cvetanovska,Henk J. Blom,Birgit Stoffel-Wagner,Heike Kölsch,Michael Weller,Frank Jessen +12 more
TL;DR: It is suggested that AD is associated with lower CSF SAM levels and that this is at least partly due to an association of the APOE4 allele with reduced SAM levels in the CSF.
Journal ArticleDOI
Prosurvival Effect of DHCR24/Seladin-1 in Acute and Chronic Responses to Oxidative Stress
Katrin Kuehnle,Arames Crameri,Roland E. Kälin,Paola Luciani,Susanna Benvenuti,Alessandro Peri,Francesca Ratti,Monica Rodolfo,Luka Kulic,Frank L. Heppner,Roger M. Nitsch,M. Hasan Mohajeri +11 more
TL;DR: A dual capacity of DHCR24/seladin-1 is revealed, which appears to be involved in two mechanistically independent prosurvival effects, exerting an acute response and a chronic response to oxidative stress.