L
Luke I Chen
Researcher at Duke University
Publications - 3
Citations - 811
Luke I Chen is an academic researcher from Duke University. The author has contributed to research in topics: Sp1 transcription factor & Transactivation. The author has an hindex of 3, co-authored 3 publications receiving 764 citations. Previous affiliations of Luke I Chen include University of California, Los Angeles.
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Journal ArticleDOI
Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan
Pei Chen,Juei-Jueng Lin,Chin-Song Lu,Chin-Song Lu,Cheung-Ter Ong,Peiyuan F. Hsieh,Chih-Chao Yang,Chih-Ta Tai,Shey-Lin Wu,Cheng-Hsien Lu,Yung-Chu Hsu,Hsiang-Yu Yu,Hsiang-Yu Yu,Long-Sun Ro,Long-Sun Ro,Chung-Ta Lu,Chung-Ta Lu,Chun-Che Chu,Chun-Che Chu,Jing-Jane Tsai,Yu-Hsiang Su,Sheng-Hsing Lan,Sheng-Feng Sung,Shu-Yi Lin,Hui-Ping Chuang,Li-Chen Huang,Ying Ju Chen,Pei-Joung Tsai,Hung-Ting Liao,Yu-Hsuan Lin,Chien-Hsiun Chen,Wen-Hung Chung,Wen-Hung Chung,Shuen-Iu Hung,Jer-Yuarn Wu,Chi-Feng Chang,Luke I Chen,Yuan-Tsong Chen,Yuan-Tsong Chen,Chen-Yang Shen,Chen-Yang Shen +40 more
TL;DR: The identification of subjects carrying the HLA-B*1502 allele and the avoidance of carbamazepine therapy in these subjects was strongly associated with a decrease in the incidence of carbazepine-induced SJS-TEN.
Journal ArticleDOI
The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator.
Luke I Chen,T. Nishinaka,K. Kwan,I. Kitabayashi,K. Yokoyama,Y.-H. F. Fu,S. Grunwald,Robert Chiu +7 more
TL;DR: Findings provide evidence for a functional link between two distinct classes of oncoproteins, RB and c-Jun, that are involved in the control of cell growth, and also define a novel mechanism for the regulation of c-jun expression.
Journal ArticleDOI
A unique cathepsin-like protease isolated from CV-1 cells is involved in rapid degradation of retinoblastoma susceptibility gene product, RB, and transcription factor SP1
TL;DR: The purified SPase suggested that an alternative pathway inactivates the function of RB in controlling cell growth, and a possible role of SPase may be to affect the stability of important regulators involved in controlling cellular proliferation and differentiation.