Ying Ju Chen

TL;DR: The identification of subjects carrying the HLA-B*1502 allele and the avoidance of carbamazepine therapy in these subjects was strongly associated with a decrease in the incidence of carbazepine-induced SJS-TEN.

TL;DR: Two new loci are reported, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10−8) and may lead to a better understanding of the role of immune activation and inflammation in Kawasaki Disease pathogenesis.

TL;DR: The Han Chinese cell and Genome Bank project was jointly supported by NRPGM and Academia Sinica and aims were to document the genetic diversity of Han Chinese in Taiwan at the beginning of the 21st century, and to create a bank of material that will prevent the repetitive collection of genetic material from the general public by the academic and medical community.

TL;DR: Evaluating the expression of these genes may help identify patients with progressive adenomas, helping to improve treatment, and identify genes with differential copy number alterations and progressively dysregulated expression.

TL;DR: Repl replication studies of the BLK and CD40 loci in populations of Korean and European descent suggest that peripheral B cells play a pathogenic role during the acute stage of Kawasaki disease, and associative data suggest a role for B cells during acute KD.