L
Lynn A. Bristol
Researcher at Johns Hopkins University
Publications - 9
Citations - 3818
Lynn A. Bristol is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Motor neuron. The author has an hindex of 7, co-authored 9 publications receiving 3675 citations.
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Journal ArticleDOI
Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate
Jeffrey D. Rothstein,Margaret Dykes-Hoberg,Carlos A. Pardo,Lynn A. Bristol,Lin Jin,Ralph W. Kuncl,Yoshikatsu Kanai,Matthias A. Hediger,Yanfeng Wang,Jerry P Schielke,Devin Franklin Welty +10 more
TL;DR: It is suggested that glial glutamate transporters provide the majority of functional glutamate transport and are essential for maintaining low extracellular glutamate and for preventing chronic glutamate neurotoxicity.
Journal ArticleDOI
Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis.
Chien Liang Glenn Lin,Lynn A. Bristol,Lin Jin,Margaret Dykes-Hoberg,Thomas O. Crawford,Lora Clawson,Jeffrey D. Rothstein +6 more
TL;DR: It is suggested that the loss of EAAT2 in ALS is due to aberrant mRNA and that these aberrant mRNAs could result from RNA processing errors, and could be important in the pathophysiology of neurodegenerative disease and in excitotoxicity.
Journal ArticleDOI
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons
TL;DR: The hypothesis that the loss of motor neurons in familial amyotrophic lateral sclerosis could be due to a reduction in SOD1 activity, possibly potentiated by inefficient glutamate transport, is supported.
Journal ArticleDOI
Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex.
TL;DR: These studies suggest that the dramatic abnormalities in EAAT2 may be due to translational or post‐ translational processes.
Journal ArticleDOI
TGFβ Trophic Factors Differentially Modulate Motor Axon Outgrowth and Protection from Excitotoxicity
Tony W. Ho,Lynn A. Bristol,Carol Coccia,Yun Li,Jeffrey Milbrandt,Eugene M. Johnson,Lin Jin,Osnat Bar-Peled,John W. Griffin,Jeffrey D. Rothstein +9 more
TL;DR: The results suggest that the neurite outgrowth-promoting effect of GDNF is mediated through the PI3K and MAP kinase pathways, and the neuroprotective effect ofGDNF appears to be through a separate pathway.