M
M. D. Posthumus
Researcher at University Medical Center Groningen
Publications - 18
Citations - 1498
M. D. Posthumus is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Arthritis & Rheumatoid arthritis. The author has an hindex of 15, co-authored 18 publications receiving 1383 citations.
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Journal ArticleDOI
Humoral responses after influenza vaccination are severely reduced in patients with rheumatoid arthritis treated with rituximab.
Sander van Assen,Albert Holvast,Cornelis A. Benne,M. D. Posthumus,Miek A. van Leeuwen,Alexandre E. Voskuyl,Marlies Blom,Anke P. Risselada,Aalzen de Haan,Johanna Westra,Cees G. M. Kallenberg,Marc Bijl +11 more
TL;DR: Rituximab reduces humoral responses following influenza vaccination in RA patients, with a modestly restored response 6-10 months after ritUXimab administration, and previously vaccinated patients in the rituxIMab-treated group had higher pre- and post vaccination GMTs for the A/H1N1 strain.
Journal ArticleDOI
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci
Alexandra Zhernakova,Alexandra Zhernakova,Alexandra Zhernakova,Eli A. Stahl,Eli A. Stahl,Gosia Trynka,Soumya Raychaudhuri,Eleanora A. Festen,Lude Franke,Harm-Jan Westra,Rudolf S N Fehrmann,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Brian Thomson,Namrata Gupta,Jihane Romanos,Ross McManus,Anthony W. Ryan,Graham Turner,Elisabeth Brouwer,M. D. Posthumus,Elaine F. Remmers,Francesca Tucci,René E. M. Toes,Elvira Grandone,Maria Cristina Mazzilli,Anna Rybak,Bożena Cukrowska,Marieke J H Coenen,Timothy R D J Radstake,Piet L. C. M. van Riel,Yonghong Li,Paul I.W. de Bakker,Peter K. Gregersen,Jane Worthington,Katherine A. Siminovitch,Lars Klareskog,Tom W J Huizinga,Cisca Wijmenga,Robert M. Plenge,Robert M. Plenge +41 more
TL;DR: A meta-analysis of two published GWAS on celiac disease and rheumatoid arthritis confirmed that 4 gene loci previously established in either CD or RA are associated with the other autoimmune disease at combined P<5×10−8, and implicate antigen presentation and T-cell activation as a shared mechanism of disease pathogenesis.
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Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.
Alexandra Zhernakova,Behrooz Z. Alizadeh,Behrooz Z. Alizadeh,Marianna Bevova,Miek A. van Leeuwen,Marieke J H Coenen,Barbara Franke,Lude Franke,M. D. Posthumus,David A. van Heel,Gerrit van der Steege,Timothy R D J Radstake,Pilar Barrera,Bart O. Roep,Bobby P. C. Koeleman,Bobby P. C. Koeleman,Cisca Wijmenga,Cisca Wijmenga +17 more
TL;DR: The results replicate and extend the association found in the KIAA1109/Tenr/IL2/ IL2/IL21 gene region with autoimmune diseases, implying that this locus is a general risk factor for multiple autoimmune diseases.
Journal ArticleDOI
LRegulation of cytokine-induced HW-1 alpha expression in rheumatoid synovial fibroblasts
Johanna Westra,Elisabeth Brouwer,Reinhard Bos,M. D. Posthumus,Berber Doornbos-van der Meer,Cees G. M. Kallenberg,Pieter C. Limburg +6 more
TL;DR: It was shown that cytokine‐induced mRNA expression of HIF‐1α was inhibited by the PI3K inhibitor, and cytokine stimulation induced VEGF mRNA and protein production, but no significant effect of kinase inhibition was found on VEGf production in cytokine-stimulated RSF.
Journal ArticleDOI
Serum levels of matrix metalloproteinase-3 in relation to the development of radiological damage in patients with early rheumatoid arthritis
M. D. Posthumus,Pieter Limburg,Johanna Westra,H. Cats,R.E. Stewart,M.A. van Leeuwen,M. H. Van Rijswijk +6 more
TL;DR: The serum MMP-3 level seems to be an indicator for the development of radiological damage in patients with early RA and appears to be particularly indicative of cartilage degradation.