M
M. E. Zayed
Researcher at King Saud University
Publications - 50
Citations - 1651
M. E. Zayed is an academic researcher from King Saud University. The author has contributed to research in topics: Chemistry & Environmental science. The author has an hindex of 17, co-authored 30 publications receiving 1131 citations.
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Journal ArticleDOI
The Multifaceted Role of Curcumin in Cancer Prevention and Treatment
Muthu K. Shanmugam,Grishma Rane,Madhu Mathi Kanchi,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Benny K. H. Tan,Alan Prem Kumar,Gautam Sethi,Gautam Sethi,Gautam Sethi +11 more
TL;DR: The current review focuses on the diverse molecular targets modulated by curcumin that contribute to its efficacy against various human cancers.
Journal ArticleDOI
NF‑κB in cancer therapy
Feng Li,Jingwen Zhang,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Alan Prem Kumar,Kwang Seok Ahn,Gautam Sethi,Gautam Sethi,Gautam Sethi +10 more
TL;DR: The diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression are highlighted.
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Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy.
Xiaoyun Dai,Jingwen Zhang,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Alan Prem Kumar,Kwang Seok Ahn,Gautam Sethi +8 more
TL;DR: Both apoptotic and nonapoptotic pathways activated by TRAIL are summarized, as well as recent advances in developing TRAIL–receptor agonists for cancer therapy.
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Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer
Kanjoormana Aryan Manu,Muthu K. Shanmugam,Lalitha Ramachandran,Feng Li,Kodappully Sivaraman Siveen,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Frank Arfuso,Alan Prem Kumar,Kwang Seok Ahn,Gautam Sethi,Gautam Sethi,Gautam Sethi +13 more
TL;DR: Results demonstrate that isorhamnetin can significantly enhance the anti-tumor effects of capecitabine through the negative regulation of NF-κB regulated oncogenic genes.
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Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells.
Seung Ho Baek,Jeong-Hyeon Ko,Hanwool Lee,Jinhong Jung,Moonkyoo Kong,Jung-woo Lee,Junhee Lee,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Seok-Geun Lee,Bum Sang Shim,Gautam Sethi,Gautam Sethi,Sung-Hoon Kim,Woong Mo Yang,Jae-Young Um,Kwang Seok Ahn +17 more
TL;DR: The results suggest that resveratrol blocks STAT3 signaling pathway through induction of SOCS-1, thus attenuating STAT3 phosphorylation and proliferation in SCCHN cells.