Maarit Rein

TL;DR: This review focuses on some of the major factors affecting the bioavailability of the aforementioned bioactive food compounds.

TL;DR: Inhibition studies showed that efflux of hesperetin conjugates to the apical side involved active transport, which from the pattern of inhibition appeared to involve mainly BCRP, and showed that B CRP-mediated transport could be a limiting step for he Speretin bioavailability.

TL;DR: The data suggest that the nature and substitution position of (-)-epicatechin conjugation are major determinants of the metabolic fate in the body, influencing whether the compound is effluxed into the lumen or absorbed into the blood and subsequently excreted.

TL;DR: The data elucidate the pathways of metabolism of dietary hesperidin in vivo and will facilitate better design of mechanistic studies both in vitro and in vitro.

TL;DR: A chiral HPLC method to separate S- and R-hesperetin on an analytical and semipreparative scale indicates that for these end points, including intestinal metabolism and transport and EpRE-mediated gene induction, experiments performed with racemic hesperetin may adequately reflect what can be expected for the naturally occurring S-enantiomer.