M
Maarten J. Titulaer
Researcher at Erasmus University Rotterdam
Publications - 131
Citations - 15905
Maarten J. Titulaer is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Encephalitis & Autoimmune encephalitis. The author has an hindex of 49, co-authored 116 publications receiving 11887 citations. Previous affiliations of Maarten J. Titulaer include Erasmus University Medical Center & Autonomous University of Barcelona.
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Journal ArticleDOI
A clinical approach to diagnosis of autoimmune encephalitis
Francesc Graus,Maarten J. Titulaer,Ramani Balu,Susanne M. Benseler,Christian G. Bien,Tania Cellucci,Irene Cortese,Russell C. Dale,Jeffrey M. Gelfand,Michael D. Geschwind,Carol A. Glaser,Jérôme Honnorat,Romana Höftberger,Takahiro Iizuka,Sarosh R. Irani,Eric Lancaster,Frank Leypoldt,Harald Prüss,Alexander Rae-Grant,Markus Reindl,Myrna R. Rosenfeld,Kevin Rostasy,Albert Saiz,Arun Venkatesan,Angela Vincent,Klaus Peter Wandinger,Patrick Waters,J. Dalmau,J. Dalmau +28 more
TL;DR: Through logical differential diagnosis, levels of evidence for autoimmune encephalitis (possible, probable, or definite) are achieved, which can lead to prompt immunotherapy.
Journal ArticleDOI
Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study
Maarten J. Titulaer,Lindsey McCracken,Iñigo Gabilondo,Thaís Armangue,Carol A. Glaser,Takahiro Iizuka,Lawrence S. Honig,Susanne M. Benseler,Izumi Kawachi,Eugenia Martinez-Hernandez,Eugenia Martinez-Hernandez,Esther Aguilar,Nuria Gresa-Arribas,Nicole Ryan-Florance,Abiguei Torrents,Albert Saiz,Myrna R. Rosenfeld,Myrna R. Rosenfeld,Rita J. Balice-Gordon,Francesc Graus,Josep Dalmau,Josep Dalmau,Josep Dalmau +22 more
TL;DR: Most patients with anti-NMDAR encephalitis respond to immunotherapy; second-line immunotherapy is usually effective when first-line treatments fail, and outcomes continued to improve for up to 18 months after symptom onset.
Journal ArticleDOI
Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study
Nuria Gresa-Arribas,Maarten J. Titulaer,Abiguei Torrents,Esther Aguilar,Lindsey McCracken,Frank Leypoldt,Amy J. Gleichman,Amy J. Gleichman,Rita J. Balice-Gordon,Myrna R. Rosenfeld,David A. Lynch,David A. Lynch,Francesc Graus,Josep Dalmau,Josep Dalmau +14 more
TL;DR: The sensitivity of NMDA receptor antibody testing is higher in CSF than in serum, and antibody titres were higher in patients with poor outcome than in those with good outcome, emphasising the importance of including CSF in antibody studies, and that antibody titre can complement clinical assessments.
Journal ArticleDOI
Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies
Mar Petit-Pedrol,Thaís Armangue,Thaís Armangue,Xiaoyu Peng,Luis Bataller,Tania Cellucci,Rebecca Davis,Lindsey McCracken,Eugenia Martinez-Hernandez,Warren P. Mason,Michael C. Kruer,David G. Ritacco,Wolfgang Grisold,Brandon F. Meaney,Carmen Alcalá,Peter A.E. Sillevis-Smitt,Maarten J. Titulaer,Rita J. Balice-Gordon,Francesc Graus,Josep Dalmau +19 more
TL;DR: High titres of serum and CSF GABAA receptor antibodies are associated with a severe form of encephalitis with seizures, refractory status epilepticus, or both and are potentially treatable.
Journal ArticleDOI
An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models.
Josep Dalmau,Thaís Armangue,Jesús Planagumà,Marija Radosevic,Francesco Mannara,Frank Leypoldt,Christian Geis,Eric Lancaster,Maarten J. Titulaer,Myrna R. Rosenfeld,Myrna R. Rosenfeld,Francesc Graus +11 more
TL;DR: Animal models have started to reveal the complexity of the underlying pathogenic mechanisms and will lead to novel treatments beyond immunotherapy, and future studies should aim at identifying prognostic biomarkers and treatments that accelerate recovery.