M
Madhukumar Venkatesh
Researcher at Albert Einstein College of Medicine
Publications - 18
Citations - 2295
Madhukumar Venkatesh is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Pregnane X receptor & Nuclear receptor. The author has an hindex of 12, co-authored 18 publications receiving 1816 citations. Previous affiliations of Madhukumar Venkatesh include University of Mysore & Yeshiva University.
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Journal ArticleDOI
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
Bret D. Wallace,Hongwei Wang,Kimberly Terry Lane,John E. Scott,Jillian Orans,Ja Seol Koo,Madhukumar Venkatesh,Christian Jobin,Li An Yeh,Sridhar Mani,Matthew R. Redinbo +10 more
TL;DR: Crystal structures revealed the molecular basis of selectivity, and in vivo studies showed that an inhibitor protected mice from irinotecan-induced toxicity, and drugs may be designed to inhibit undesirable enzyme activities in essential microbial symbiotes to enhance chemotherapeutic efficacy.
Journal ArticleDOI
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.
Madhukumar Venkatesh,Subhajit Mukherjee,Hongwei Wang,Hao Li,Katherine Sun,Alexandre P. Benechet,Zhijuan Qiu,Leigh Maher,Matthew R. Redinbo,Robert S. Phillips,James C. Fleet,Sandhya Kortagere,Paromita Mukherjee,Alessio Fasano,Jessica Le Ven,Jeremy K. Nicholson,Marc E. Dumas,Kamal M. Khanna,Sridhar Mani +18 more
TL;DR: It is shown that microbial-specific indoles regulated intestinal barrier function through the xenobiotic sensor, pregnane X receptor (PXR), and a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4.
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Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity
Bret D. Wallace,Adam B. Roberts,Rebecca M. Pollet,James D. Ingle,Kristen A. Biernat,S.J. Pellock,Madhukumar Venkatesh,Leah Guthrie,Sara O'Neal,Sara J. Robinson,Makani Dollinger,Esteban Figueroa,Sarah R. McShane,Rachel D. Cohen,Jian Jin,Stephen V. Frye,William C. Zamboni,Charles Pepe-Ranney,Sridhar Mani,Libusha Kelly,Matthew R. Redinbo +20 more
TL;DR: The crystal structures of representative β-glucuronidases from the Firmicutes Streptococcus agalactiae and Clostridium perfringens and the Proteobacterium Escherichia coli are reported and it is established that β- glucuronidsase inhibition does not alter the serum pharmacokinetics of irinotecan or its metabolites in mice.
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Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.
Hongwei Wang,Madhukumar Venkatesh,Hao Li,Regina Goetz,Subhajit Mukherjee,Arunima Biswas,Liang Zhu,Andreas Kaubisch,Lei Wang,James Pullman,Kathleen D. Whitney,Makoto Kuro-o,Andres I. Roig,Jerry W. Shay,Moosa Mohammadi,Sridhar Mani +15 more
TL;DR: Data indicate that colon cancer growth in the presence of a specific PXR ligand results from tumor-specific induction of FGF19, which may lead to improved therapeutic regimens for colon carcinomas.
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The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.
Hongwei Wang,Hao Li,Linda B. Moore,Michael D. L. Johnson,Jodi M. Maglich,Bryan Goodwin,Olivia R. R. Ittoop,Bruce Wisely,Katrina L. Creech,Derek J. Parks,Jon L. Collins,Timothy M. Willson,Ganjam V. Kalpana,Madhukumar Venkatesh,Wen Xie,Sool Yeon Cho,John Roboz,Matthew R. Redinbo,John T. Moore,Sridhar Mani +19 more
TL;DR: Evidence is provided that a naturally occurring phytoestrogen, coumestrol, is an antagonist of the nuclear receptor PXR (NR1I2), and mammalian two-hybrid assays and transient transcription data using ligand-binding-cavity mutant forms of PxR show that coumstrol also antagonizes coregulator recruitment.