P
Paromita Mukherjee
Researcher at Albert Einstein College of Medicine
Publications - 4
Citations - 1048
Paromita Mukherjee is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Pregnane X receptor & Signal transduction. The author has an hindex of 4, co-authored 4 publications receiving 832 citations.
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Journal ArticleDOI
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.
Madhukumar Venkatesh,Subhajit Mukherjee,Hongwei Wang,Hao Li,Katherine Sun,Alexandre P. Benechet,Zhijuan Qiu,Leigh Maher,Matthew R. Redinbo,Robert S. Phillips,James C. Fleet,Sandhya Kortagere,Paromita Mukherjee,Alessio Fasano,Jessica Le Ven,Jeremy K. Nicholson,Marc E. Dumas,Kamal M. Khanna,Sridhar Mani +18 more
TL;DR: It is shown that microbial-specific indoles regulated intestinal barrier function through the xenobiotic sensor, pregnane X receptor (PXR), and a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4.
Journal ArticleDOI
Functional Organization of the S. cerevisiae Phosphorylation Network
Dorothea Fiedler,Dorothea Fiedler,Hannes Braberg,Monika Mehta,Gal Chechik,Gerard Cagney,Gerard Cagney,Paromita Mukherjee,Andrea C. Silva,Michael Shales,Sean R. Collins,Sean R. Collins,Sake van Wageningen,Patrick Kemmeren,Frank C. P. Holstege,Jonathan S. Weissman,Jonathan S. Weissman,Michael-Christopher Keogh,Daphne Koller,Kevan M. Shokat,Kevan M. Shokat,Nevan J. Krogan +21 more
TL;DR: An epistatic miniarray profile comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and small-molecule kinases and phosphatases as well as key cellular regulators is generated, finding an enrichment of positive genetic interactions between kinases, phosphatase, and their substrates.
Journal ArticleDOI
Methodologies to decipher the cell secretome.
Paromita Mukherjee,Sridhar Mani +1 more
TL;DR: This review aims to discuss the methodologies available along with their potential advantages and disadvantages to identify secretory proteins in cell secretomes.
Journal ArticleDOI
Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR
Hao Li,Matthew R. Redinbo,Madhukumar Venkatesh,Sean Ekins,Anik Chaudhry,Nicolin Bloch,Abdissa Negassa,Paromita Mukherjee,Ganjam V. Kalpana,Sridhar Mani +9 more
TL;DR: A yeast-based genetic method to discover novel nuclear receptor interactions with ligands that associate with surface binding sites is suggested and significantly expands understanding of antagonist binding sites on the surface of PXR and suggest new avenues to regulate this receptor for clinical applications.