M
Marc E. Dumas
Researcher at Imperial College London
Publications - 15
Citations - 2751
Marc E. Dumas is an academic researcher from Imperial College London. The author has contributed to research in topics: Gut flora & Transplantation. The author has an hindex of 7, co-authored 10 publications receiving 2166 citations.
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Journal Article
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity : relationship with gut microbiome richness and ecology [plus Supplementary data]
Maria Carlota Dao,Amandine Everard,Judith Aron-Wisnewsky,Nataliya Sokolovska,Edi Prifti,Eric O. Verger,Brandon D. Kayser,Florence Levenez,Julien Chilloux,Lesley Hoyles,Marc E. Dumas,Salwa W. Rizkalla,Joël Doré,Patrice D. Cani,Karine Clément,S. Le Mouhaër,Aurélie Cotillard,Sean Kennedy,Nicolas Pons,Mathieu Almeida,Benoit Quinquis,Nathalie Galleron,Jean-Michel Batto,Pierre Renault,Jean-Daniel Zucker,S. Dusko Ehrlich,Hervé M. Blottière,Marion Leclerc,Catherine Juste,T. De Wouters,Patricia Lepage +30 more
TL;DR: In this paper, the authors evaluated the association between faecal A. muciniphila abundance and microbial gene richness after calorie restriction (CR) in overweight and obese adults.
Journal ArticleDOI
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.
Madhukumar Venkatesh,Subhajit Mukherjee,Hongwei Wang,Hao Li,Katherine Sun,Alexandre P. Benechet,Zhijuan Qiu,Leigh Maher,Matthew R. Redinbo,Robert S. Phillips,James C. Fleet,Sandhya Kortagere,Paromita Mukherjee,Alessio Fasano,Jessica Le Ven,Jeremy K. Nicholson,Marc E. Dumas,Kamal M. Khanna,Sridhar Mani +18 more
TL;DR: It is shown that microbial-specific indoles regulated intestinal barrier function through the xenobiotic sensor, pregnane X receptor (PXR), and a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4.
Journal ArticleDOI
Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies.
Olivier Cloarec,Marc E. Dumas,Johan Trygg,Andrew Craig,Richard H. Barton,John C. Lindon,Jeremy K. Nicholson,Elaine Holmes +7 more
TL;DR: The interpretation of chemometric models using combined back-scaled loading plots and variable weights demonstrates that this peak position variation can be handled successfully and also often provides additional information on the physicochemical variations in metabonomic data sets.
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Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome
Saeed Shoaie,Pouyan Ghaffari,Petia Kovatcheva-Datchary,Adil Mardinoglu,Partho Sen,Estelle Pujos-Guillot,Tomas de Wouters,Catherine Juste,Salwa W. Rizkalla,Salwa W. Rizkalla,Julien Chilloux,Lesley Hoyles,Jeremy K. Nicholson,Joël Doré,Marc E. Dumas,Karine Clément,Karine Clément,Karine Clément,Fredrik Bäckhed,Fredrik Bäckhed,Jens Nielsen +20 more
TL;DR: The CASINO (Community And Systems-level INteractive Optimization) toolbox is described, a comprehensive computational platform for analysis of microbial communities through metabolic modeling that could quantitatively describe altered fecal and serum amino acid levels in response to diet intervention.
Journal ArticleDOI
Early metabolic adaptation in C57BL/6 mice resistant to high fat diet induced weight gain involves an activation of mitochondrial oxidative pathways.
Claire L. Boulangé,Sandrine P. Claus,Chieh J. Chou,Sebastiano Collino,Ivan Montoliu,Sunil Kochhar,Elaine Holmes,Serge Rezzi,Jeremy K. Nicholson,Marc E. Dumas,François-Pierre Martin +10 more
TL;DR: In the HF group, NR mice excreted relatively more hexanoylglycine, isovalerylglycines, and fewer tricarboxylic acid (TCA) cycle intermediate (succinate) in comparison to SR mice, suggesting subtle regulation of ketogenic pathways in DIO may alleviate the saturation of the TCA cycle and mitochondrial oxidative metabolism.