M
Maija Hollmén
Researcher at University of Turku
Publications - 83
Citations - 2432
Maija Hollmén is an academic researcher from University of Turku. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 20, co-authored 58 publications receiving 1796 citations. Previous affiliations of Maija Hollmén include ETH Zurich & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
Minna Tanner,Maija Hollmén,Teemu T. Junttila,A. I. Kapanen,S. Tommola,Y. Soini,H. Helin,J. Salo,Heikki Joensuu,E. Sihvo,Klaus Elenius,Klaus Elenius,Jorma Isola +12 more
TL;DR: HER-2/neu amplification is common in the intestinal type of gastric carcinoma, and it is associated with a poor outcome, and this hypothesis deserves to be investigated in clinical trials.
Journal ArticleDOI
Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women
Eveliina Munukka,Juha P. Ahtiainen,Pere Puigbò,Sirpa Jalkanen,Katja Pahkala,Anniina Keskitalo,Anniina Keskitalo,Urho M. Kujala,Sami Pietilä,Maija Hollmén,Laura L. Elo,Pentti Huovinen,Giuseppe D'Auria,Satu Pekkala +13 more
TL;DR: Exercise training modified the gut microbiome without greatly affecting systemic metabolites or body composition, and it is proposed that especially Akkermansia and Proteobacteria are exercise-responsive taxa.
Journal ArticleDOI
Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils.
Akira Takeda,Maija Hollmén,Denis Dermadi,Junliang Pan,Junliang Pan,Kevin Brulois,Riina Kaukonen,Tapio Lönnberg,Pia Boström,Ilkka Koskivuo,Heikki Irjala,Masayuki Miyasaka,Masayuki Miyasaka,Marko Salmi,Eugene C. Butcher,Eugene C. Butcher,Sirpa Jalkanen +16 more
TL;DR: The profiling of 33,000 lymphatic endothelial cells in human lymph nodes by single-cell RNA sequencing revealed six major types of human LECs, and unveils a previously undefined role for medullary L ECs in human immunity.
Journal ArticleDOI
Characterization of macrophage--cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer
TL;DR: How different cancer cells educate the host cells to support tumor growth is demonstrated and might explain why high infiltration of macrophages in TNBC tumors associates with poor prognosis.
Journal ArticleDOI
G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer
Maija Hollmén,Sinem Karaman,Simon Schwager,Angela Lisibach,Ailsa J. Christiansen,Mikael Maksimow,Zsuzsanna Varga,Sirpa Jalkanen,Michael Detmar +8 more
TL;DR: Results indicate that G- CSF promotes the anti-inflammatory phenotype of tumor-induced macrophages when CSF-1R is inhibited and therefore caution against the use of M-CSF/CSF- 1R targeting agents in tumors with high G-CSf expression.