L
Laura L. Elo
Researcher at Åbo Akademi University
Publications - 183
Citations - 6265
Laura L. Elo is an academic researcher from Åbo Akademi University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 31, co-authored 146 publications receiving 4654 citations. Previous affiliations of Laura L. Elo include University of Turku & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
A survey of best practices for RNA-seq data analysis
Ana Conesa,Pedro Madrigal,Pedro Madrigal,Sonia Tarazona,David Gomez-Cabrero,Alejandra Cervera,Andrew McPherson,Michał Wojciech Szcześniak,Daniel J. Gaffney,Laura L. Elo,Xuegong Zhang,Ali Mortazavi +11 more
TL;DR: All of the major steps in RNA-seq data analysis are reviewed, including experimental design, quality control, read alignment, quantification of gene and transcript levels, visualization, differential gene expression, alternative splicing, functional analysis, gene fusion detection and eQTL mapping.
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Comparison of software packages for detecting differential expression in RNA-seq studies
TL;DR: A systematic comparison of eight widely used software packages and pipelines for detecting differential expression between sample groups in a practical research setting is performed and general guidelines for choosing a robust pipeline are provided.
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A systematic evaluation of normalization methods in quantitative label-free proteomics
TL;DR: It is found that variance stabilization normalization (Vsn) reduced variation the most between technical replicates in all examined data sets and performed consistently well in the differential expression analysis.
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Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility
Henna Kallionpää,Laura L. Elo,Essi Laajala,Juha Mykkänen,Isis Ricaño-Ponce,Matti Vaarma,Teemu D. Laajala,Heikki Hyöty,Jorma Ilonen,Riitta Veijola,Tuula Simell,Cisca Wijmenga,Mikael Knip,Harri Lähdesmäki,Olli Simell,Riitta Lahesmaa +15 more
TL;DR: Genes and pathways related to innate immunity functions, such as the type 1 interferon (IFN) response, were active, and IFN response factors were identified as central mediators of the IFN-related transcriptional changes.
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Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.
Laura L. Elo,Henna Järvenpää,Soile Tuomela,Sunil K. Raghav,Helena Ahlfors,Helena Ahlfors,Kirsti Laurila,Bhawna Gupta,Riikka Lund,Riikka Lund,Johanna Tahvanainen,R. David Hawkins,Matej Orešič,Harri Lähdesmäki,Harri Lähdesmäki,Omid Rasool,Kanury V. Rao,Tero Aittokallio,Riitta Lahesmaa,Riitta Lahesmaa +19 more
TL;DR: In this article, the authors identified a number of direct and indirect targets of STAT6 with RNAi and integrated these data sets with detailed kinetics of IL-4-driven transcriptional changes, showing that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype.