R
Riina Kaukonen
Researcher at Åbo Akademi University
Publications - 15
Citations - 1115
Riina Kaukonen is an academic researcher from Åbo Akademi University. The author has contributed to research in topics: Cell growth & Transcription factor. The author has an hindex of 9, co-authored 14 publications receiving 849 citations. Previous affiliations of Riina Kaukonen include VTT Technical Research Centre of Finland & University of Turku.
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Journal ArticleDOI
Filopodia and adhesion in cancer cell motility
TL;DR: Data implicated that several different filopodia inducing genes may contribute in a collective manner to cancer progression and the high metastasis rates associated with basal-type breast carcinomas.
Journal ArticleDOI
Integrin endosomal signalling suppresses anoikis.
Jonna Alanko,Jonna Alanko,Anja Mai,Guillaume Jacquemet,Kristine Schauer,Riina Kaukonen,Markku Saari,Markku Saari,Bruno Goud,Johanna Ivaska,Johanna Ivaska +10 more
TL;DR: It is shown that active focal adhesion kinase (FAK), an established marker of integrin–ECM downstream signalling, localizes with active integrins on endosomes and becomes activated on them, suggesting a role for endocytosis in enhancing distinct integrin downstream signalling events.
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Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis
Antti Arjonen,Riina Kaukonen,Elina Mattila,Pegah Rouhi,Gunilla Högnäs,Harri Sihto,Bryan W. Miller,Jennifer P. Morton,Elmar Bucher,Pekka Taimen,Pekka Taimen,Reetta Virtakoivu,Yihai Cao,Yihai Cao,Owen J. Sansom,Heikki Joensuu,Johanna Ivaska +16 more
TL;DR: Data indicate that Myo10 upregulation in mutant p53-driven cancers is necessary for invasion and that plasma-membrane protrusions, such as filopodia, may serve as specialized metastatic engines.
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Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils.
Akira Takeda,Maija Hollmén,Denis Dermadi,Junliang Pan,Junliang Pan,Kevin Brulois,Riina Kaukonen,Tapio Lönnberg,Pia Boström,Ilkka Koskivuo,Heikki Irjala,Masayuki Miyasaka,Masayuki Miyasaka,Marko Salmi,Eugene C. Butcher,Eugene C. Butcher,Sirpa Jalkanen +16 more
TL;DR: The profiling of 33,000 lymphatic endothelial cells in human lymph nodes by single-cell RNA sequencing revealed six major types of human LECs, and unveils a previously undefined role for medullary L ECs in human immunity.
Journal ArticleDOI
Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function
Reetta Virtakoivu,Reetta Virtakoivu,Anja Mai,Elina Mattila,Elina Mattila,Nicola De Franceschi,Nicola De Franceschi,Susumu Y. Imanishi,Garry L. Corthals,Riina Kaukonen,Riina Kaukonen,Markku Saari,Markku Saari,Fang Cheng,Fang Cheng,Elin Torvaldson,Elin Torvaldson,Veli-Matti Kosma,Arto Mannermaa,Ghaffar Muharram,Ghaffar Muharram,Christine Gilles,John E. Eriksson,Ylermi Soini,James B. Lorens,Johanna Ivaska,Johanna Ivaska +26 more
TL;DR: A novel vimentin-ERK axis that regulates the transcriptional activity of Slug (SNAI2) is described, which identified a pivotal step in controlling the ability of Slug to organize hallmarks of EMT.