M
Maikel P. Peppelenbosch
Researcher at Erasmus University Rotterdam
Publications - 610
Citations - 25498
Maikel P. Peppelenbosch is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Signal transduction & Cancer. The author has an hindex of 74, co-authored 565 publications receiving 21791 citations. Previous affiliations of Maikel P. Peppelenbosch include University of Amsterdam & University Medical Center Groningen.
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Journal ArticleDOI
Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn’s disease
Jan M. H. van den Brande,Henri Braat,Gijs R. van den Brink,Henri H. Versteeg,Christiaan A Bauer,Inge Hoedemaeker,Catherine van Montfrans,Daan W. Hommes,Maikel P. Peppelenbosch,Sander J. H. van Deventer +9 more
TL;DR: Only infliximab was able to bind to PBL and lamina propria T cells and subsequently to induce apoptosis of activated lymphocytes, which may provide a biological basis for the difference in efficacy of the 2 TNF-alpha-neutralizing drugs.
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A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease
Henri Braat,Pieter Rottiers,Daniel W. Hommes,Nathalie Huyghebaert,Erik Remaut,Jean Paul Remon,Sander J. H. van Deventer,Sabine Neirynck,Sabine Neirynck,Maikel P. Peppelenbosch,Lothar Steidler,Lothar Steidler +11 more
TL;DR: Here it is shown that the use of genetically modified bacteria for mucosal delivery of proteins is a feasible strategy in human beings and is suitable as maintenance treatment for chronic intestinal disease.
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Potential association between COVID-19 mortality and health-care resource availability.
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Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease.
TL;DR: Infusion of infliximab in steroid refractory patients with Crohn's disease induced a clinical response but did not influence expression of activation markers, homing receptors, memory cells, Fas expression, or Bax/Bcl-2 expression on peripheral blood T lymphocytes, indicating a rapid and specific increase in apoptosis of T lymphocyte in the gut mucosa.
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Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms
TL;DR: Increased production of PA by the microbiota might be considered beneficial in the context of prevention of obesity and diabetes type 2, and PA emerges as a major mediator in the link between nutrition, gut microbiota and physiology.