M
Malte A. Karow
Researcher at University of Cologne
Publications - 7
Citations - 70
Malte A. Karow is an academic researcher from University of Cologne. The author has contributed to research in topics: Autophagy & Dictyostelium discoideum. The author has an hindex of 4, co-authored 6 publications receiving 53 citations.
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Journal ArticleDOI
ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2.
TL;DR: It is proposed that ATG16 links autophagy and the ubiquitin proteasome system, a core autophagosomal protein that is required for their enrichment in ATG8a positive puncta, which mature into autolysosomes.
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A tripeptidyl peptidase 1 is a binding partner of the Golgi pH regulator (GPHR) in Dictyostelium
Maria Stumpf,Rolf Müller,Berthold Gaßen,Regina Wehrstedt,Petra Fey,Malte A. Karow,Ludwig Eichinger,Gernot Glöckner,Angelika A. Noegel +8 more
TL;DR: Interaction of Dictyostelium tripeptidyl peptidase 1 with GPHR could be relevant for studies of the human enzyme, which is associated with a neurodegenerative disorder.
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Functional Characterisation of the Autophagy ATG12~5/16 Complex in Dictyostelium discoideum.
Malte A. Karow,Sarah Fischer,Susanne Meßling,Roman Konertz,Jana Riehl,Qiuhong Xiong,Ramesh Rijal,Prerana Wagle,Christoph S. Clemen,Christoph S. Clemen,Christoph S. Clemen,Ludwig Eichinger +11 more
TL;DR: The results confirm the essential function of the ATG12~5/16 complex in canonical autophagy, and furthermore are consistent with autophophagy-independent functions of the complex and its individual components.
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Expression of N471D strumpellin leads to defects in the endolysosomal system.
Lin Song,Ramesh Rijal,Ramesh Rijal,Malte A. Karow,Maria Stumpf,Oliver Hahn,Laura Park,Robert H. Insall,Rolf Schröder,Andreas Hofmann,Christoph S. Clemen,Christoph S. Clemen,Ludwig Eichinger +12 more
TL;DR: Deficiencies in endo-/exocytosis and lysosome morphology are caused by the N471D strumpellin mutation, which is associated with spastic paraplegia 8, and a key role for the WASH complex and its core subunit, Str, in the endolysosomal system is underscore.
Journal ArticleDOI
A convenient tool for bivariate data analysis and bar graph plotting with R
Andreas Hofmann,Andreas Hofmann,Megan Cross,Malte A. Karow,Jan Hendrik Straub,Christoph S. Clemen,Christoph S. Clemen,Ludwig Eichinger +7 more
TL;DR: The Java software jBar consists of a graphical user interface that allows the user to customize and assemble an included script for R that calculates means and standard errors/deviations for replicates of numerical bivariate data and generates presentations in the form of bar graphs.