M
Manfred Kaufmann
Researcher at University of Madeira
Publications - 275
Citations - 21664
Manfred Kaufmann is an academic researcher from University of Madeira. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 46, co-authored 266 publications receiving 20172 citations. Previous affiliations of Manfred Kaufmann include Madeira Tecnopolo & University of Porto.
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Journal ArticleDOI
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
O. Abe,R. Abe,K. Enomoto,K. Kikuchi,H. Koyama,H. Masuda,Y. Nomura,K. Sakai,K. Sugimachi,T. Tominaga,J. Uchino,M. Yoshida,J. L. Haybittle,C Davies,V. J. Harvey,T. M. Holdaway,R. G. Kay,B. H. Mason,John F. Forbes,Nicholas Wilcken,M. Gnant,Raimund Jakesz,M. Ploner,H. M. A. Yosef,C. Focan,J. P. Lobelle,U. Peek,G. D. Oates,Janet T. Powell,M. Durand,L. Mauriac,A. Di Leo,Stella Dolci,M.J. Piccart,M. B. Masood,D. Parker,J. J. Price,Pierre Hupperets,Sue Jackson,Joseph Ragaz,Donna L. Berry,Gloria Broadwater,C. Cirrincione,Hyman B. Muss,Larry Norton,Raymond B. Weiss,H. Abu-Zahra,S. M. Portnoj,Michael J. Baum,Jack Cuzick,Joan Houghton,David Riley,N. H. Gordon,H. L. Davis,A. Beatrice,J. Mihura,A. Naja,Y. Lehingue,P. Romestaing,J. B. Dubois,Thierry Delozier,J. Mace-Lesec'h,P. Rambert,O. Andrysek,J. Barkmanova,Julie Owen,P. Meier,A Howell,G. C. Ribeiro,R. Swindell,R Alison,J Boreham,Matthew Clarke,Rory Collins,Sarah C. Darby,P. Elphinstone,Vaughan Evans,Jon Godwin,Richard Gray,C. S. Harwood,C. Hicks,Spencer L. James,Elizabeth MacKinnon,Paul McGale,Theresa McHugh,Graham M. Mead,Richard Peto,Yisong Wang,J. Albano,C. F. de Oliveira,H. Gervasio,J. Gordilho,H Johansen,Henning T. Mouridsen,Rebecca Gelman,J.R. Harris,I. C. Henderson,Charles L. Shapiro,K. W. Andersen,C. K. Axelsson,M. Blichert-Toft,S. Moller,Jens Overgaard,Marie Overgaard,Carsten Rose,B. Cartensen,T. Palshof,H. J. Trampisch,Otilia Dalesio,E.G.E. de Vries,Sjoerd Rodenhuis,H. van Tinteren,R. L. Comis,Nancy E. Davidson,Nicholas J. Robert,George W. Sledge,Douglass C. Tormey,William C. Wood,David Cameron,Udi Chetty,P. Forrest,W. Jack,J. Rossbach,Jan G. M. Klijn,A. D. Treurniet-Donker,W. L. J. van Putten,Alberto Costa,Umberto Veronesi,H. Bartelink,L. Duchateau,C. Legrand,RJ Sylvester,J.A. van der Hage,C.J.H. van de Velde,M. P. Cunningham,R. Catalano,R. H. Creech,Jacques Bonneterre,P. Fargeot,Pierre Fumoleau,Pierre Kerbrat,Moïse Namer,Walter Jonat,Manfred Kaufmann,Martin Schumacher,G. von Minckwitz,G. Bastert,H. Rauschecker,R. Sauer,Willi Sauerbrei,A.J. Schauer,A. de Schryver,L. Vakaet,M. Belfiglio,A. Nicolucci,F. Pellegrini,M. Sacco,M. Valentini,C. S. McArdle,D. C. Smith,E. Galligioni,Francesco Boccardo,AU Rubagotti,D. M. Dent,C. A. Gudgeon,A. Hacking,A. Erazo,J. Y. Medina,M. Izuo,Y. Morishita,H. Takei,I.S. Fentiman,John L. Hayward,R D Rubens,D. Skilton,H. Graeff,Fritz Jänicke,C. Meisner,H. R. Scheurlen,D. von Fournier,Urania Dafni,G. Fountzilas,P. Klefstrom,Carl Blomqvist,T. Saarto,R. Margreiter,Bernard Asselain,R. J. Salmon,J. R. Vilcoq,Rodrigo Arriagada,Christopher Hill,A. Laplanche,M. G. Le,M. Spielmann,Paolo Bruzzi,E. Montanaro,R. Rosso,M. R. Sertoli,M. Venturini,Dino Amadori,J. Benraadt,M. Kooi,A. O. van de Velde,J. A. van Dongen,J. B. Vermorken,Monica Castiglione,F. Cavalli,A. S. Coates,J. Collins,JF Forbes,Richard D. Gelber,A. Goldhirsch,J. Lindtner,Karen N. Price,C. M. Rudenstam,H.-J. Senn,Judith M Bliss,Clair Chilvers,R. C. Coombes,Emma Hall,Michel Marty,R. V. Borovik,G. Brufman,H. Hayat,E. Robinson,N. Wigler,Gianni Bonadonna,T. Camerini,G. De Palo,M. Del Vecchio,F. Formelli,Pinuccia Valagussa,A Martoni,F. Pannuti,G. Cocconi,A. Colozza,R. Camisa,K. Aogi,S. Takashima,T. Ikeda,K. Inokuchi,K. Sawa,H. Sonoo,S. Korzeniowski,J. Skolyszewski,M. Ogawa,J. Yamashita,J. Bonte,R. Christiaens,Robert Paridaens,W. Van den Boegart,P. Martin,S. Romain,T. Hakes,Clifford A. Hudis,R. Wittes,G. Giokas,D. Kondylis,B. Lissaios,R. de la Huerta,M. G. Sainz,R. Altemus,K. Cowan,David N. Danforth,Allen S. Lichter,Marc E. Lippman,Joyce A. O'Shaughnessy,Lori J. Pierce,Seth M. Steinberg,D. Venzon,JoAnne Zujewski,A. Paradiso,M. De Lena,F. Schittulli,J. Myles,J. L. Pater,Kathleen I. Pritchard,Stewart J. Anderson,G. Bass,Anna Brown,John Bryant,J. Costantino,James J. Dignam,Bernard Fisher,C Redmond,Sam Wieand,Norman Wolmark,I. M. Jackson,Mike K. Palmer,JN Ingle,Vera J. Suman,Nils-Olof Bengtsson,H. Jonsson,Lars-Gunnar Larsson,J. P. Lythgoe,M. Kissin,Bjørn Erikstein,E Hannisdal,A. B. Jacobsen,J. E. Varhaug,S. Gundersen,Martin Hauer-Jensen,H. Host,R. Nissen-Meyer,Roger W. Blamey,A. Mitchell,Morgan Da,J.F.R. Robertson,M. Di Palma,G. Mathe,J. L. Misset,R. M. Clark,Mitch Levine,K Morimoto,Y. Takatsuka,E. Crossley,Al Harris,Denis Talbot,Mark Taylor,B. di Blasio,V. Ivanov,Vladimir Semiglazov,J. Brockschmidt,M. R. Cooper,H. Ueo,Carla I. Falkson,Roger A'Hern,Stanley W. Ashley,T. J. Powles,Ian E. Smith,John Yarnold,J.-C. Gazet,N. Cocoran,N. Deshpande,L. di Martino,P. Douglas,A. Lindtner,G Notter,A. J. S. Bryant,G. H. Ewing,L. A. Firth,J. L. Krushen-Kosloski,L. Foster,W.D. George,Helen J. Stewart,P. Stroner,Per-Uno Malmström,Torgil Möller,Stefan Rydén,Ingrid Tengrup,Lena Tennvall-Nittby,J. Carstenssen,M. Dufmats,Thomas Hatschek,Bo Nordenskjöld,Martin Söderberg,John T. Carpenter,KS Albain,J. Crowley,Stuart A. Green,Silvana Martino,CK Osborne,Peter M. Ravdin,U. Glas,Ulla Johansson,L E Rutqvist,T. Singnomklao,Arne Wallgren,Rudolf Maibach,Beat Thürlimann,Hermann Brenner,A. Hercbergs,M Yoshimoto,Gerrit DeBoer,Alexander H.G. Paterson,JW Meakin,T. Panzarella,Y. Shan,Y. F. Shao,X. Wang,D. B. Zhao,Z. M. Chen,H. C. Pan,J. Bahi,M. Reid,M. Spittle,G. P. Deutsch,F. Senanayake,D. L. W. Kwong,Angelo Raffaele Bianco,Chiara Carlomagno,M. De Laurentiis,S. De Placido,Aman U. Buzdar,Tae C Smith,Jonas Bergh,Lars Holmberg,Göran Liljegren,Jan Nilsson,M. Seifert,P. Sevelda,C. C. Zielinsky,R. B. Buchanan,M. Cross,G.T. Royle,Janet A. Dunn,Robert Kerrin Hills,Michael Lee,J. M. Morrison,D. Spooner,A. Litton,Rowan T. Chlebowski,H. Caffier +412 more
TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
Journal Article
Polychemotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.
C. Focan,Seth M. Steinberg,M. Blichert-Toft,JF Forbes,Rory Collins,Stewart J. Anderson,R. Margreiter,C. S. Harwood,K. W. Andersen,G. Beighton,R. V. Borovik,EA Clarke,T Yasutomi,Walter Jonat,E. Mari,O. Abe,Richard Peto,Richard Gray,J. B. Vermorken,Bernard Asselain,Mitchell A Harris,Ingrid Tengrup,PC Lara,J.L. Laplanche,Sue Jackson,RJ Sylvester,H. Ueo,Pierre Fumoleau,R. Sauer,William C. Wood,Willi Sauerbrei,Rebecca Gelman,J. C. Redmond,Angelo Raffaele Bianco,Rodrigo Arriagada,M Hauer,Marie Overgaard,M. P. Cunningham,John L. Hayward,M. Kissin,Owen,W. Jack,Cooper,J. L. Pater,M. Ogawa,Jon Godwin,N Scorpiglione,Mike K. Palmer,H Johansen,H. Hayat,Aman U. Buzdar,Hyman B. Muss,H. Sonoo,David Riley,G. Brufman,MJ Piccart-Gebhart,John Bryant,R. Nissen,H. Koyama,J. Uchino,D. Parker,J Mace,M. Durand,G. Cocconi,Y. Morishita,CF Oliveira,R. L. Comis,A. Goldhirsch,M. Spielmann,J. E. Varhaug,Carsten Rose,J-B Bonte,A. R. Coates,C. S. McArdle,J. J. Price,Janet T. Powell,L. M. Vecchio,Martin Schumacher,Matthew Clarke,A. Nicolucci,Larry Norton,G. Mathe,H.H. Tooth,R. Huerta,A. Erazo Velásquez,Norman Wolmark,N. H. Gordon,Joan Houghton,Michael J. Baum,S. Gundersen,R. H. Creech,Gianni Bonadonna,D. C. Smith,R. J. Salmon,D.F. Hacking,R. C. Coombes,Kathleen I. Pritchard,Y. Lehingue,James J. Dignam,L. Mauriac,J. Myles,Sam Wieand,Spencer L. James,Carla I. Falkson,Carl Blomqvist,M. Belfiglio,H. L. Davis,AU Rubagotti,V. Gouon-Evans,K. Sawa,F. Pannuti,Francesco Boccardo,R. Abe,I.S. Fentiman,K. Sakai,T. M. Holdaway,Gloria Broadwater,Pinuccia Valagussa,M. G. Le,J. B. Dubois,Tae C Smith,J. Collins,M. Izuo,Manfred Kaufmann,C. K. Axelsson,Nancy E. Davidson,R Simon,AO de Lima,J. Yamashita,H. J. Trampisch,Jack Cuzick,S. Takashima,E. Robinson,G. Fountzilas,Lippman amp,Donna L. Berry,Henning T. Mouridsen,R. Wittes,A Kodric-Brown,R. M. Clark,D Jackson,N Corcoran,Umberto Veronesi,D. M. Dent,K Morimoto,C Davies,Y. Takatsuka,B Carstensen,Bernard Fisher,Lars-Gunnar Larsson,Cjh van de Velde,E. F. Lau,E. Greaves,P. Meier,Roger W. Blamey,John F. Forbes,Hma Yosef,R. Swindell,G. Bastert,Moïse Namer,JN Ingle,J. L. Misset,R. G. Kay,J. Benraadt,Christopher Hill,S. Romain,J. L. Haybittle,Karen N. Price,N. Wigler,R. Catalano,Judith M Bliss,Jfr Robertson,Lori J. Pierce,Vera J. Suman,Monica Castiglione,R D Rubens,H. Host,J. Albano,K. Kikuchi,A.J. Schauer,B. H. Mason,A Lewit-Bentley,Thierry Delozier,H.-J. Senn,Vilcoq,B Dil Blasio,T. Hakes,Douglass C. Tormey,J. Skolyszewski,K Welvaart,T. Tominaga,C. M. Rudenstam,JA Dongen,J. Costantino,S Bartholomeus,G. C. Mead,Michel Marty,Richard D. Gelber,M. Yoshida,McLaughlin,Mitch Levine,Joseph Ragaz,K. Enomoto,D Fournier,SB Schryver,V. J. Harvey,Udi Chetty,Y. Nomura,J. Lindtner,P. Forrest,N Cole Robert,Jacques Bonneterre,J. P. Lobelle,A. Bengry-Howell,P. Romestaing,I. C. Henderson,P Martin-Sanz,T. Palshof,G. C. Ribeiro,E Hannisdal,A. H. Gervasio,K. Sugimachi,Charles L. Shapiro,R. E. Crossley,C. Cirrincione,I. M. Jackson,Michael Gnant +226 more
TL;DR: The age-specific benefits of polychemotherapy appeared to be largely irrespective of menopausal status at presentation, oestrogen receptor status of the primary tumour, and of whether adjuvant tamoxifen had been given.
Journal ArticleDOI
Definition and Impact of Pathologic Complete Response on Prognosis After Neoadjuvant Chemotherapy in Various Intrinsic Breast Cancer Subtypes
Gunter von Minckwitz,Michael Untch,Jens-Uwe Blohmer,SD Costa,Holger Eidtmann,Peter A. Fasching,Bernd Gerber,Wolfgang Eiermann,Jörn Hilfrich,Jens Huober,Christian Jackisch,Manfred Kaufmann,Gottfried E. Konecny,Carsten Denkert,Valentina Nekljudova,Keyur Mehta,Sibylle Loibl +16 more
TL;DR: The exact definition of pathologic complete response (pCR) and its prognostic impact on survival in intrinsic breast cancer subtypes is uncertain this paper, however, it is known that pCR is associated with long-term outcome of 6,377 patients with primary breast cancer receiving neoadjuvant anthracycline-taxane-based chemotherapy in seven randomized trials.
Journal ArticleDOI
Meta-Analysis of Breast Cancer Outcomes in Adjuvant Trials of Aromatase Inhibitors Versus Tamoxifen
Mitch Dowsett,Jack Cuzick,Jim Ingle,Alan S. Coates,John F. Forbes,Judith M Bliss,Marc Buyse,Michael J. Baum,Aman U. Buzdar,Marco Colleoni,Charles Coombes,Claire Snowdon,Michael Gnant,Raimund Jakesz,Manfred Kaufmann,Francesco Boccardo,Jon Godwin,C Davies,Richard Peto +18 more
TL;DR: There was no convincing heterogeneity in the proportional recurrence reduction with respect to age, nodal status, tumor grade, or progesterone receptor status and no indication of an increase in nonbreast deaths with AIs in either cohort.
Journal ArticleDOI
Trastuzumab Beyond Progression in Human Epidermal Growth Factor Receptor 2–Positive Advanced Breast Cancer: A German Breast Group 26/Breast International Group 03-05 Study
Gunter von Minckwitz,Andreas du Bois,Marcus Schmidt,Nicolai Maass,Tanja Cufer,Felix E. de Jongh,E. Maartense,Christoph C. Zielinski,Manfred Kaufmann,Wolfgang R. Bauer,Klaus Baumann,Michael R. Clemens,Ralph Duerr,Christoph Uleer,Martin Andersson,Robert Stein,Valentina Nekljudova,Sibylle Loibl +17 more
TL;DR: Continuation of trastuzumab beyond progression was not associated with increased toxicity and showed a significant improvement in overall response and time to progression compared with capecitabine alone in women with HER-2-positive breast cancer who experienced progression during trastzumab treatment.