M
Manfred Lindau
Researcher at Cornell University
Publications - 118
Citations - 7331
Manfred Lindau is an academic researcher from Cornell University. The author has contributed to research in topics: Exocytosis & Vesicle. The author has an hindex of 45, co-authored 114 publications receiving 6875 citations. Previous affiliations of Manfred Lindau include Max Planck Society & University of Seville.
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Improved surface-patterned platinum microelectrodes for the study of exocytotic events.
TL;DR: Platinum electrodes fabricated using contact photolithography are able to record single exocytotic events with high resolution and should be suitable for highly parallel electrode arrays allowing simultaneous measurements of single events from multiple cells.
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Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils.
TL;DR: The nature and regulation of the release mechanism of eosinophil secretion appear to be very similar to that of the mast cell and neutrophil.
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Noradrenaline inhibits exocytosis via the G protein βγ subunit and refilling of the readily releasable granule pool via the αi1/2 subunit
TL;DR: The molecular mechanisms responsible for the ‘distal’ effect by which noradrenaline blocks exocytosis in the β‐cell were examined and a novel effect of NA was discovered, inducing a marked retardation of the rate of refilling of the readily releasable pool of secretory granules.
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Capacitance flickers and pseudoflickers of small granules, measured in the cell-attached configuration.
TL;DR: The study of exocytosis of single small granules from human neutrophils by capacitance recordings in the cell-attached configuration concludes that non-stepwise capacitance changes must be interpreted with caution, since a number of factors go into determining cell or patch admittance.
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Compound exocytosis of granules in human neutrophils
TL;DR: Analysis of exocytosis of single granules from human neutrophils by the high‐resolution cell‐attached patch‐clamp capacitance technique found that 1.5% of the capacitance steps was greater than 5 fF, i.e., significantly larger than steps expected for exocytic events, which may be a mechanism for efficient targeting of release during exocyTosis.