Mao Yang

TL;DR: It is shown that, during necroptosis, MLKL-dependent calcium (Ca2+) influx and phosphatidylserine (PS) exposure on the outer leaflet of the plasma membrane preceded loss of PM integrity.

TL;DR: In this paper, the authors describe the consequences of defective LC3-associated phagocytosis in vivo and show that mice lacking any of several components of the LAP pathway show increased serum levels of inflammatory cytokines and autoantibodies, glomerular immune complex deposition, and evidence of kidney damage.

TL;DR: The data support a protective role for LANDO in microglia in neurodegenerative pathologies resulting from β-amyloid deposition, and identify a novel non-canonical function of several autophagy proteins in the conjugation of LC3 to Rab5+, clathrin+ endosomes containing β-amide.

TL;DR: It is found that the anti-tumor effects of LAP impairment require tumor-infiltrating T cells, dependent upon STING and the type I interferon response, and autophagy proteins in the myeloid cells of the tumor microenvironment contribute to immune suppression of T lymphocytes by effecting LAP.

TL;DR: BOK is a bona fide yet unconventional effector of MOMP that can trigger apoptosis in the absence of both BAX and BAK, but unlike the canonical effectors, BOK appears to be constitutively active and unresponsive to antagonistic effects of the antiapoptotic BCL-2 proteins.