Sunmin Park

TL;DR: In this paper, the authors describe the consequences of defective LC3-associated phagocytosis in vivo and show that mice lacking any of several components of the LAP pathway show increased serum levels of inflammatory cytokines and autoantibodies, glomerular immune complex deposition, and evidence of kidney damage.

TL;DR: It is shown that, contrary to expectation, autophagic capacity does not correlate with the outcome of M. tuberculosis infection in vivo, and ATG5 plays a unique role in protection against M.culosis by preventing PMN-mediated immunopathology.

TL;DR: It is shown that the cassette of autophagy proteins involved in the conjugation of microtubule-associated protein 1 light chain 3 (LC3) to phosphatidylethanolamine, including Atg7, Atg3, and the Atg12- atg5-Atg16L1 complex play crucial roles in the control of T. gondii in vitro and in vivo.

TL;DR: It is demonstrated that autophagy is essential for maintaining ocular immune privilege and directly implicate the homeostatic process of Autophagy in blinding eye disease and identify novel pathways for therapeutic intervention in uveitis.

TL;DR: Deletion of autophagy-related genes in myeloid cells dampen virus-induced systemic inflammation, creating an environment that fosters efficient MHV68 reactivation from latency.