M
Maphoshane Nchabeleng
Researcher at Sefako Makgatho Health Sciences University
Publications - 44
Citations - 1066
Maphoshane Nchabeleng is an academic researcher from Sefako Makgatho Health Sciences University. The author has contributed to research in topics: Vaccination & HIV vaccine. The author has an hindex of 11, co-authored 37 publications receiving 782 citations. Previous affiliations of Maphoshane Nchabeleng include National Health Laboratory Service & University of South Africa.
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Journal ArticleDOI
Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study.
Glenda E. Gray,Mary Allen,Zoe Moodie,Gavin J. Churchyard,Linda-Gail Bekker,Maphoshane Nchabeleng,Koleka Mlisana,Barbara Metch,Guy de Bruyn,Mary H. Latka,Surita Roux,Matsontso Mathebula,Nivashnee Naicker,Constance. Ducar,Donald K. Carter,Adrian Puren,Niles. Eaton,M. Juliana McElrath,Michael N. Robertson,Lawrence Corey,James G. Kublin +20 more
TL;DR: The MRKAd5 HIV- 1 vaccine did not prevent HIV-1 infection or lower viral-load setpoint; however, stopping the trial early probably compromised the ability to draw conclusions.
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Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study
Glenda E. Gray,Glenda E. Gray,Zoe Moodie,Barbara Metch,Peter B. Gilbert,Linda-Gail Bekker,Gavin J. Churchyard,Maphoshane Nchabeleng,Koleka Mlisana,Fatima Laher,Surita Roux,Kathryn Therese. Mngadi,Craig Innes,Matsontso Mathebula,Mary Allen,M. Julie McElrath,Michael N. Robertson,James G. Kublin,Lawrence Corey +18 more
TL;DR: The increased risk of HIV-1 acquisition in vaccine recipients, irrespective of number of doses received, warrants further investigation to understand the biological mechanism and is cautioned against further use of the Ad5 vector for HIV vaccines.
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Vaccine Efficacy of ALVAC-HIV and Bivalent Subtype C gp120–MF59 in Adults
Glenda Gray,Glenda Gray,Glenda Gray,Linda-Gail Bekker,Fatima Laher,Mookho Malahleha,Mary Allen,Zoe Moodie,Nicole Grunenberg,Yunda Huang,Doug Grove,Brittany Prigmore,Jia J. Kee,David Benkeser,John Hural,Craig Innes,Erica Lazarus,Graeme Meintjes,Nivashnee Naicker,Dishiki Jenny Kalonji,Maphoshane Nchabeleng,Modulakgotla Sebe,Nishanta Singh,Philip Kotze,Sheetal Kassim,Thozama Dubula,Vimla Naicker,William Brumskine,Cleon N. Ncayiya,Amy Ward,Nigel Garrett,Girisha Kistnasami,Zakir Gaffoor,Pearl Selepe,Philisiwe B. Makhoba,Matsontso Mathebula,Pamela Mda,Tania Adonis,Katlego S. Mapetla,Bontle Modibedi,Tricia Philip,Gladys Kobane,Carter Bentley,Shelly Ramirez,Simbarashe Takuva,Megan Jones,Mpho Sikhosana,Millicent Atujuna,Michele P. Andrasik,Nima S. Hejazi,Adrian Puren,Lubbe Wiesner,Sanjay Phogat,Sanjay Phogat,Carlos Diaz Granados,Marguerite Koutsoukos,Olivier Van Der Meeren,Susan W. Barnett,Niranjan Kanesa-thasan,James G. Kublin,M. Juliana McElrath,Peter B. Gilbert,Holly Janes,Lawrence Corey +63 more
TL;DR: In this article, a canarypox-protein HIV vaccine regimen (ALVAC-HIV plus AIDSVAX B/E) showed modest efficacy in reducing infection in Thailand.
Journal ArticleDOI
Outbreak of multidrug-resistant tuberculosis in South Africa undetected by WHO-endorsed commercial tests: an observational study.
Ndivhuho Agnes Makhado,Edith Matabane,Mauro Faccin,Claire Pinçon,Agathe Jouet,Fairouz Boutachkourt,Léonie Goeminne,Cyril Gaudin,Gugu Maphalala,Patrick Beckert,Stefan Niemann,Jean-Charles Delvenne,Jean-Charles Delvenne,Michel Delmée,Lufuno Razwiedani,Maphoshane Nchabeleng,Maphoshane Nchabeleng,Philip Supply,Bouke C. de Jong,Emmanuel André +19 more
TL;DR: Consistent with Deeplex-MycTB genotypic profiles, whole-genome sequencing revealed concurrent silent spread in South Africa of a MDR tuberculosis strain lineage extending from the eSwatini outbreak and at least another independently emerged Ile491Phe-bearing lineage.
Journal ArticleDOI
Antibiotic resistance of Streptococcus agalactiae isolated from pregnant women in Garankuwa, South Africa
John Y. Bolukaoto,Charles M. Monyama,Martina O. Chukwu,Sebotse M. Lekala,Maphoshane Nchabeleng,Motlatji Reratilwe Bonnie Maloba,Rooyen T. Mavenyengwa,Rooyen T. Mavenyengwa,Sogolo Lucky Lebelo,Sam T. Monokoane,Charles Tshepuwane,Sylvester R. Moyo +11 more
TL;DR: The study reaffirmed the appropriateness of penicillin as the antibiotic of choice for treating GBS infection, however it identified the challenges of resistance to macrolides and lincosamides used as alternative drugs for individuals allergic toPenicillin.