Mara L. Macdonald

TL;DR: The induction of endothelial vessel networks in engineered skeletal muscle tissue constructs using a three-dimensional multiculture system consisting of myoblasts, embryonic fibroblasts and endothelial cells coseeded on highly porous, biodegradable polymer scaffolds is described.

TL;DR: In this paper, the first layer-by-layer (LbL) films capable of microgram-scale release of the biologic Bone Morphogenetic Protein 2 (BMP-2), which is capable of directing the host tissue response to create bone from native progenitor cells.

TL;DR: PEM films that sequester physiological amounts of osteogenic rhBMP-2 and angiogenic rhVEGF₁₆₅ (recombinant human vascular endothelial growth factor) in different ratios in a degradable LbL tetralayer repeat architecture are presented, suggesting more complete remodeling due to an increased local vascular network.

TL;DR: LbL polyelectrolyte films constructed with the model protein lysozyme and a hydrolytically degradable and biocompatible synthetic polycation are characterized and have promise as a tool for exploring protein modulation of the interaction between implanted surfaces and the cells they contact.

TL;DR: In this paper, the loading and release of FGF-2 from synthetic hydrolytically degradable multilayer thin films of various architectures is explored; drug loading was tunable using at least three parameters (number of nanolayers, counterpolyanion, and type of degradably polycation) and yielded values of 7-45 ng/cm(2) of fibroblast growth factor 2. Release time varied between 24 h and approximately five days.