Journal ArticleDOI
The value of antimicrobial peptides in the age of resistance
Maria Magana,Muthuirulan Pushpanathan,Ana L. Santos,Leon G. Leanse,Michael Fernandez,Anastasios Ioannidis,Marc A. Giulianotti,Yiorgos Apidianakis,Steven B. Bradfute,Andrew L. Ferguson,Artem Cherkasov,Mohamed N. Seleem,Clemencia Pinilla,Cesar de la Fuente-Nunez,Themis Lazaridis,Themis Lazaridis,Tianhong Dai,Richard A. Houghten,Robert E. W. Hancock,George P. Tegos +19 more
TLDR
The benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens are identified, advances in the deployment of novel promising antimacterial peptides are highlighted, and the needs and priorities in designing focused development strategies taking into account the most advanced tools available are underlined.Abstract:
Accelerating growth and global expansion of antimicrobial resistance has deepened the need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear advantages over conventional antibiotics which include slower emergence of resistance, broad-spectrum antibiofilm activity, and the ability to favourably modulate the host immune response. Broad bacterial susceptibility to antimicrobial peptides offers an additional tool to expand knowledge about the evolution of antimicrobial resistance. Structural and functional limitations, combined with a stricter regulatory environment, have hampered the clinical translation of antimicrobial peptides as potential therapeutic agents. Existing computational and experimental tools attempt to ease the preclinical and clinical development of antimicrobial peptides as novel therapeutics. This Review identifies the benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens, highlights advances in the deployment of novel promising antimicrobial peptides, and underlines the needs and priorities in designing focused development strategies taking into account the most advanced tools available.read more
Citations
More filters
Journal ArticleDOI
Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields
TL;DR: This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved.
Journal ArticleDOI
A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides.
Katrina Browne,Sudip Chakraborty,Renxun Chen,Mark D. P. Willcox,David StClair Black,William R. Walsh,Naresh Kumar +6 more
TL;DR: The therapeutic potential of peptide-based antimicrobials is detailed, as well as the challenges needed to overcome in order for clinical translation, and how this novel class of antimicrobial compound may address the need for effective antibiotics are explored.
Journal ArticleDOI
Chemically modified and conjugated antimicrobial peptides against superbugs.
TL;DR: In this paper, a review summarises recent synthetic efforts and their impact on analogue design as well as their various applications in AMP development, including modifications that have been reported to enhance antimicrobial activity including lipidation, glycosylation and multimerization through to the broad application of novel bio-orthogonal chemistry.
Journal ArticleDOI
Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields
Antonio Moretta,Carmen Scieuzo,Anna Maria Petrone,Rosanna Salvia,Michele Dario Manniello,Antonio Franco,Donatella Lucchetti,Antonio Vassallo,Heiko Vogel,Alessandro Sgambato,Patrizia Falabella +10 more
TL;DR: Antimicrobial peptides (AMPs) have aroused great interest as potential next-generation antibiotics, since they are bioactive small proteins, naturally produced by all living organisms, and representing the first line of defense against fungi, viruses and bacteria as discussed by the authors.
Journal ArticleDOI
Antimicrobial peptides: mechanism of action, activity and clinical potential.
Qiyu Zhang,Zhi-Bin Yan,Yueming Meng,Xiang-Yu Hong,Gang Shao,Jun-Jie Ma,Xurui Cheng,Jun Liu,Jian Kang,Jian Kang,Caiyun Fu +10 more
TL;DR: Antimicrobial peptides (AMPs) as mentioned in this paper are an excellent candidate to overcome antibiotic resistance, they demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity.
References
More filters
Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.
Journal ArticleDOI
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.
Evelina Tacconelli,Elena Carrara,Alessia Savoldi,Stéphan Juergen Harbarth,Marc Mendelson,Dominique L Monnet,Céline Pulcini,Gunnar Kahlmeter,Jan Kluytmans,Yehuda Carmeli,Marc Ouellette,Kevin Outterson,Jean B. Patel,Marco Cavaleri,Edward Cox,Christopher R. Houchens,M Lindsay Grayson,Paul Hansen,Nalini Singh,Ursula Theuretzbacher,Nicola Magrini,Aaron O. Aboderin,Seif Al-Abri,Nordiah Awang Jalil,Nur Benzonana,Sanjay Bhattacharya,Adrian Brink,Francesco Robert Burkert,Otto Cars,Giuseppe Cornaglia,Oliver J. Dyar,Alexander W. Friedrich,Ana Cristina Gales,Sumanth Gandra,Christian G. Giske,Debra A. Goff,Herman Goossens,Thomas Gottlieb,Manuel Guzman Blanco,Waleria Hryniewicz,Deepthi Kattula,Timothy Jinks,Souha S. Kanj,Lawrence Kerr,Marie-Paule Kieny,Yang Soo Kim,Roman S. Kozlov,Jaime Labarca,Ramanan Laxminarayan,Karin Leder,Leonard Leibovici,Gabriel Levy-Hara,Jasper Littman,Surbhi Malhotra-Kumar,Vikas Manchanda,Lorenzo Moja,Babacar Ndoye,Angelo Pan,David L. Paterson,Mical Paul,Haibo Qiu,Pilar Ramon-Pardo,Jesús Rodríguez-Baño,Maurizio Sanguinetti,Sharmila Sengupta,Mike Sharland,Massinissa Si-Mehand,Lynn L. Silver,Wonkeung Song,Martin Steinbakk,Jens Thomsen,Guy E. Thwaites,Jos W. M. van der Meer,Nguyen Van Kinh,Silvio Vega,Maria Virginia Villegas,Agnes Wechsler-Fördös,Heiman F. L. Wertheim,Evelyn Wesangula,Neil Woodford,Fidan O Yilmaz,Anna Zorzet +81 more
TL;DR: Future development strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and Gram-negative bacteria, and include antibiotic-resistant bacteria responsible for community-acquired infections.
Journal ArticleDOI
Bioactive microbial metabolites.
TL;DR: The short history, specific features and future prospects of research of microbial metabolites, including antibiotics and other bioactive metabolites, are summarized.
Journal ArticleDOI
A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
Journal ArticleDOI
Activities at the Universal Protein Resource (UniProt)
Rolf Apweiler,Alex Bateman,Maria Jesus Martin,Claire O'Donovan,Michele Magrane,Yasmin Alam-Faruque,Emanuele Alpi,Ricardo Antunes,J Arganiska,EB Casanova,Benoit Bely,M Bingley,Carlos Bonilla,Ramona Britto,Borisas Bursteinas,WM Chan,Gayatri Chavali,Elena Cibrian-Uhalte,A Da Silva,M De Giorgi,Tunca Doğan,F. Fazzini,Paul Gane,Leyla Jael Garcia Castro,Penelope Garmiri,Emma Hatton-Ellis,Reija Hieta,Rachael P. Huntley,Duncan Legge,W Liu,Jie Luo,Alistair MacDougall,Prudence Mutowo,Andrew Nightingale,Sandra Orchard,Klemens Pichler,Diego Poggioli,Sangya Pundir,L Pureza,Guoying Qi,S. Rosanoff,Rabie Saidi,Tony Sawford,Aleksandra Shypitsyna,Edd Turner,Volynkin,Tony Wardell,Xavier Watkins,Hermann Zellner,Matthew Corbett,M Donnelly,P van Rensburg,Mickael Goujon,Hamish McWilliam,Rodrigo Lopez,Ioannis Xenarios,Lydie Bougueleret,Alan Bridge,Sylvain Poux,Nicole Redaschi,Lucila Aimo,Andrea H. Auchincloss,Kristian B. Axelsen,Parit Bansal,Delphine Baratin,P-A Binz,M. C. Blatter,Brigitte Boeckmann,Jerven Bolleman,Emmanuel Boutet,Lionel Breuza,C Casal-Casas,E de Castro,Lorenzo Cerutti,Elisabeth Coudert,Béatrice A. Cuche,M Doche,Dolnide Dornevil,Séverine Duvaud,Anne Estreicher,L Famiglietti,M Feuermann,Elisabeth Gasteiger,Sebastien Gehant,Gerritsen,Arnaud Gos,Nadine Gruaz-Gumowski,Ursula Hinz,Chantal Hulo,J. James,Florence Jungo,Guillaume Keller,Lara,P Lemercier,J Lew,Damien Lieberherr,Thierry Lombardot,Xavier D. Martin,Patrick Masson,Anne Morgat,Teresa Batista Neto,Salvo Paesano,Ivo Pedruzzi,Sandrine Pilbout,Monica Pozzato,Manuela Pruess,Catherine Rivoire,Bernd Roechert,Maria Victoria Schneider,Christian J. A. Sigrist,K Sonesson,S Staehli,Andre Stutz,Shyamala Sundaram,Michael Tognolli,Laure Verbregue,A-L Veuthey,Cathy H. Wu,Cecilia N. Arighi,Leslie Arminski,Chuming Chen,Yongxing Chen,John S. Garavelli,Hongzhan Huang,Kati Laiho,Peter B. McGarvey,Darren A. Natale,Baris E. Suzek,C. R. Vinayaka,Qinghua Wang,Yuqi Wang,L-S Yeh,Yerramalla,Jie Zhang +133 more
TL;DR: The mission of the Universal Protein Resource (UniProt) is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequences and functional annotation.