M
Marc A. Vittoria
Researcher at Boston University
Publications - 10
Citations - 247
Marc A. Vittoria is an academic researcher from Boston University. The author has contributed to research in topics: Hippo signaling pathway & Hippo signaling. The author has an hindex of 4, co-authored 10 publications receiving 79 citations.
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Journal ArticleDOI
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells.
Ryan J. Quinton,Amanda DiDomizio,Marc A. Vittoria,Kristýna Kotýnková,Carlos J. Ticas,Sheena Patel,Yusuke Koga,Jasmine Vakhshoorzadeh,Nicole M. Hermance,Taruho S. Kuroda,Neha Parulekar,Alison M. Taylor,Amity L. Manning,Joshua D. Campbell,Joshua D. Campbell,Neil J. Ganem +15 more
TL;DR: This paper showed that WGD+ cells are more dependent than WGD-cells on signalling from the spindle-assembly checkpoint, DNA-replication factors and proteasome function and identified KIF18A, which encodes a mitotic kinesin protein, as being specifically required for the viability of whole-genome doubling (WGD+) cells.
Posted ContentDOI
Whole genome doubling confers unique genetic vulnerabilities on tumor cells
Ryan J. Quinton,Amanda DiDomizio,Marc A. Vittoria,Carlos J. Ticas,Sheena Patel,Yusuke Koga,Kristyna Kotynkova,Jasmine Vakhshoorzadeh,Nicole M. Hermance,Taruho S. Kuroda,Neha Parulekar,Alison M. Taylor,Amity L. Manning,Joshua D. Campbell,Neil J. Ganem +14 more
TL;DR: It is shown that WGD gives rise to common genetic traits that are accompanied by unique vulnerabilities, and KIF18A, which encodes for a mitotic kinesin, is identified as being specifically required for the viability of WGD+ cells.
Journal ArticleDOI
Identification of the kinase STK25 as an upstream activator of LATS signaling.
Sanghee Lim,Nicole M. Hermance,Tenny Mudianto,Tenny Mudianto,Hatim M. Mustaly,Ian Paolo Morelos Mauricio,Marc A. Vittoria,Ryan J. Quinton,Brian W. Howell,Hauke Cornils,Amity L. Manning,Neil J. Ganem +11 more
TL;DR: It is demonstrated that loss of STK25 promotes YAP/TAZ activation and enhanced cellular proliferation, even under normally growth-suppressive conditions both in vitro and in vivo, and is significantly focally deleted across a wide spectrum of human cancers.
Journal ArticleDOI
A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation.
Marc A. Vittoria,Elizabeth M Shenk,Kevin P. O’Rourke,Amanda F. Bolgioni,Sanghee Lim,Victoria Kacprzak,Ryan J. Quinton,Neil J. Ganem +7 more
TL;DR: A comprehensive gain-of-function genome-wide screen to identify microRNAs (miRNAs) that are sufficient to promote the proliferation of tetraploid cells reveals several avenues through which tetraPloid cells may regain the proliferative capacity necessary to drive tumorigenesis.
Journal ArticleDOI
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel.
TL;DR: Live-cell imaging protocols to assess cell fate decisions following treatment with the anti-mitotic drug paclitaxel are described and methods to visualize whether mitotically arrested cells die directly from mitosis or slip back into interphase are demonstrated.