M
Marc-Henri Stern
Researcher at Curie Institute
Publications - 196
Citations - 12240
Marc-Henri Stern is an academic researcher from Curie Institute. The author has contributed to research in topics: Gene & Breast cancer. The author has an hindex of 49, co-authored 168 publications receiving 9402 citations. Previous affiliations of Marc-Henri Stern include Necker-Enfants Malades Hospital & French Institute of Health and Medical Research.
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Journal ArticleDOI
Abstract P1-07-01: Real time detection of ESR1 mutation in blood by droplet digital PCR in the PADA-1 trial: Feasibility and cross-validation with NGS
Céline Callens,François-Clément Bidard,Anais Curto-Taribo,O. Trabelsi-Grati,Samia Melaabi,Suzette Delaloge,Anne-Claire Hardy-Bessard,Thomas Bachelot,Florian Clatot,Thibault De La Motte Rouge,Jean-Luc Canon,Laurent Arnould,Fabrice Andre,Sandrine Marques,Marc-Henri Stern,Jean-Yves Pierga,Anne Vincent Salomon,Emmanuelle Jeannot,Frédérique Berger,Ivan Bièche,Anne Pradines +20 more
TL;DR: The sample flow of this first-in-its-class trial, from April 2017 to March 2021, and the cross-validation of ddPCR results with NGS showed an excellent correlation, as well as the number of ESR1mut copies detected per mL of plasma together with the Mutant Allele Frequency (MAF).
Journal ArticleDOI
Single Droplet Digital Polymerase Chain Reaction for Comprehensive and Simultaneous Detection of Mutations in Hotspot Regions
Charles Decraene,Amanda Bortolini Silveira,Marc Michel,François-Clément Bidard,Jean-Yves Pierga,Marc-Henri Stern,Charlotte Proudhon +6 more
TL;DR: Drop-off ddPCR displays comparable sensitivity to conventional ddPCRs with the advantage of detecting a greater number of mutations in a single reaction, which is cost-effective, conserves precious sample material, and can also be used as a discovery tool when mutations are not known a priori.
Proceedings ArticleDOI
Abstract 87: Micropapillary breast carcinoma is characterized by deregulation of genes involved in cell division control
Nadège Gruel,Vanessa Benhamo,Tatiana Popova,Arnaud Gauthier,Ilaria Cascone,Laurent Arnould,Paul Fréneaux,Aurélie Cédenot,Odette Mariani,Jaydutt Bhalshankar,Gaëlle Pierron,Patricia de Cremoux,Fabien Reyal,Séverine Alran,Paul Cottu,Alain Fourquet,Xavier Sastre,Marc-Henri Stern,Jacques Camonis,Olivier Delattre,Anne Vincent-Salomon +20 more
TL;DR: Analysis of biological specificities of invasive micropapillary carcinoma of the breast showed that IMPC constitutes a distinct entity from ER+ N+ LVI+ IDC with, in particular, high frequencies of bi-nucleated cells, 17q gains and amplifications associated with 6q losses of heterozygosity.
Journal ArticleDOI
Prospective validation in epithelial tumors of a gene expression predictor of liver metastasis derived from uveal melanoma
Petros Tsantoulis,Mauro Delorenzi,Mauro Delorenzi,Ivan Bièche,Sophie Vacher,Pascale Mariani,Nathalie Cassoux,Alexandre Houy,Alexandre Houy,Marc-Henri Stern,Marc-Henri Stern,Sergio Roman-Roman,Pierre-Yves Dietrich,Arnaud Roth,Wulfran Cacheux +14 more
TL;DR: The expression of PTP4A3 and JPH1 correlates with risk of liver metastasis in colorectal cancer and breast cancer, and the underlying biological mechanism is an interesting area for further research.