Marc-Henri Stern

TL;DR: An integromic analysis of gene alterations that modulate transforming growth factor β-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas provides a broad molecular perspective relevant for future functional and therapeutic studies of the diverse cancer pathways mediated by the TGF-β superfamily.

TL;DR: A graphical user interface for visualization and first level analysis of molecular profiles is developed and currently in use at the Institut Curie for cancer research projects involving CGH arrays, transcriptome arrays, SNP (single nucleotide polymorphism) arrays, loss of heterozygosity results (LOH), and Chromatin ImmunoPrecipitation arrays (ChIP chips).

TL;DR: This study provides the first integrated analysis of the inactive X chromosome in the context of breast cancer and establishes that epigenetic erosion of the active X can lead to the disappearance of the Barr body in breast cancer cells.

TL;DR: MTS1 inactivation, observed in at least 80% of T-ALL, is the most consistent genetic defect found in this disease to date and strongly suggest that MTS1 is the functional target of rearrangements in T-all.

TL;DR: A new hypermutated phenotype due to germline mutations and subsequent somatic loss of heterozygosity of MBD4 is described, and a dramatic response to the PD-1 inhibitor pembrolizumab in a patient with a MBD 4-inactivatedHypermutated uveal melanoma is presented.