M
Marc L. Goalstone
Researcher at University of Colorado Denver
Publications - 27
Citations - 1658
Marc L. Goalstone is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 15, co-authored 27 publications receiving 1577 citations. Previous affiliations of Marc L. Goalstone include Anschutz Medical Campus & United States Department of Veterans Affairs.
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Journal ArticleDOI
Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells.
Monica Montagnani,Inga Golovchenko,Injune Kim,Gou Young Koh,Marc L. Goalstone,Ameya N. Mundhekar,Mette Johansen,Dennis F. Kucik,Michael J. Quon,Boris Draznin +9 more
TL;DR: It is concluded that inhibition of the metabolic branch of insulin signaling leads to an enhanced mitogenic action of insulin in endothelial cells.
Journal ArticleDOI
Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology
TL;DR: Some of the effects of insulin resistance and mechanisms of potentially detrimental influence of hyperinsulinemia in the presence of metabolic insulin resistance are discussed.
Journal Article
Molecular mechanisms of insulin resistance that impact cardiovascular biology. Perspectives in diabetes
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Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women
Marc-Andre Cornier,W. Troy Donahoo,Rocio I. Pereira,Inga Gurevich,Rickard Westergren,Sven Enerbäck,Peter J. Eckel,Marc L. Goalstone,James O. Hill,Robert H. Eckel,Boris Draznin +10 more
TL;DR: Overall, changes in Si were associated with the degree of weight loss, and the macronutrient composition of a hypocaloric diet may need to be adjusted to correspond to the state of Si.
Journal ArticleDOI
Effect of Insulin on Cell Cycle Progression in MCF-7 Breast Cancer Cells: DIRECT AND POTENTIATING INFLUENCE *
James Chappell,J. Wayne Leitner,Scott Solomon,Inga Golovchenko,Marc L. Goalstone,Boris Draznin +5 more
TL;DR: The ability of insulin to increase the cellular amounts of geranylgeranylated Rho-A results in potentiation of the LPA effect on cyclin E expression and degradation of p27Kip1 and cell cycle progression in MCF-7 breast cancer cells.