Effect of Insulin on Cell Cycle Progression in MCF-7 Breast Cancer Cells: DIRECT AND POTENTIATING INFLUENCE *
James Chappell,J. Wayne Leitner,Scott Solomon,Inga Golovchenko,Marc L. Goalstone,Boris Draznin +5 more
TLDR
The ability of insulin to increase the cellular amounts of geranylgeranylated Rho-A results in potentiation of the LPA effect on cyclin E expression and degradation of p27Kip1 and cell cycle progression in MCF-7 breast cancer cells.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-10-12 and is currently open access. It has received 115 citations till now. The article focuses on the topics: Cyclin D & Cyclin E.read more
Citations
More filters
Journal ArticleDOI
Diabetes mellitus and risk of breast cancer: a meta-analysis.
TL;DR: A meta‐analysis of case–control and cohort studies indicates that diabetes is associated with an increased risk of breast cancer.
Journal ArticleDOI
Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women
Marc J. Gunter,Donald R. Hoover,Herbert Yu,Sylvia Wassertheil-Smoller,Thomas E. Rohan,JoAnn E. Manson,Jixin Li,Gloria Y.F. Ho,Xiaonan Xue,Garnet L. Anderson,Robert C. Kaplan,Tiffany G. Harris,Barbara V. Howard,Judith Wylie-Rosett,Robert D. Burk,Howard D. Strickler +15 more
TL;DR: It is suggested that hyperinsulinemia is an independent risk factor for breast cancer and may have a substantial role in explaining the obesity-breast cancer relationship.
Journal ArticleDOI
Obesity, adipocytokines, and insulin resistance in breast cancer.
TL;DR: Obesity-related increases in adipocytokine production and a reduction in adiponectin may adversely affect breast cancer outcome by their angiogenesis‐related activities, which may provide a biological mechanism by which obesity and insulin resistance are causally associated with breast cancer risk and poor prognosis.
Journal ArticleDOI
Associations of Insulin Resistance and Adiponectin With Mortality in Women With Breast Cancer
Catherine Duggan,Melinda L. Irwin,Liren Xiao,Katherine D. Henderson,Ashley Wilder Smith,Richard Baumgartner,Kathy B. Baumgartner,Leslie R. Bernstein,Rachel Ballard-Barbash,Anne McTiernan +9 more
TL;DR: Elevated HOMA scores and low levels of adiponectin, both associated with obesity, were associated with increased breast cancer mortality in breast cancer survivors.
Journal ArticleDOI
Breast cancer and obesity: an update.
TL;DR: In this paper, a review serves to stress insulin, insulin-like growth factor-I, and leptin, and their relationship to angiogenesis, and transcriptional factors in breast cancer.
References
More filters
Journal ArticleDOI
CDK inhibitors: positive and negative regulators of G1-phase progression
TL;DR: This work challenges previous assumptions about how the G1/S transition of the mammalian cell cycle is governed, helps explain some enigmatic features of cell cycle control that also involve the functions of the retinoblastoma protein (Rb) and the INK4 proteins, and changes the thinking about how either p16 loss or overexpression of cyclin D-dependent kinases contribute to cancer.
Journal ArticleDOI
Inhibitors of mammalian G1 cyclin-dependent kinases.
Journal ArticleDOI
Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.
TL;DR: A rapid method for the flow microfluorometric determination of the DNA content per cell is described, which requires a minimal amount of material, and avoids formation of cell clumps.
Journal ArticleDOI
All ras proteins are polyisoprenylated but only some are palmitoylated
TL;DR: It is shown that all ras proteins are polyisoprenylated on their C-terminal cysteine (Cys186) and palmitoylation increases the avidity of this binding and enhances their transforming activity.
Journal ArticleDOI
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.
TL;DR: Results suggest that cyclins D1 and E are rate-limiting activators of the G1-to-S phase transition and that cyclin D1 might play a specialized role in facilitating emergence from quiescence.