M
Marcela Filipová
Researcher at Academy of Sciences of the Czech Republic
Publications - 23
Citations - 215
Marcela Filipová is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 5, co-authored 13 publications receiving 130 citations. Previous affiliations of Marcela Filipová include Charles University in Prague & First Faculty of Medicine, Charles University in Prague.
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Journal ArticleDOI
Toxicity of carboxylated carbon nanotubes in endothelial cells is attenuated by stimulation of the autophagic flux with the release of nanomaterial in autophagic vesicles
Martina Orecna,Silvia H. De Paoli,Olga Janouskova,Olga Janouskova,Tseday Z. Tegegn,Marcela Filipová,John E. Bonevich,Karel Holada,Jan Simak +8 more
TL;DR: It is reported that carboxylated multiwalled carbon nanotubes induce a decrease in viability of cultured human umbilical vein endothelial cells (HUVECs) associated with the profound accumulation of autophagosomes, and pharmacological stimulation of the autophagic flux may represent a new method of cytoprotection against toxic effects of nanomaterials.
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Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia
Pavel Honsa,Pavel Honsa,Helena Pivonkova,Helena Pivonkova,David Dzamba,David Dzamba,Marcela Filipová,Miroslava Anderova +7 more
TL;DR: The data indicate that polydendrocytes in the dorsal cortex display multipotent differentiation potential after focal ischemia, and some EGFP+ cells displayed membrane properties typical for neural precursor cells, and moreover these cells expressed doublecortin – a marker of newly-derived neuronal cells.
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Glycopolymers for Efficient Inhibition of Galectin-3: In Vitro Proof of Efficacy Using Suppression of T Lymphocyte Apoptosis and Tumor Cell Migration.
Marcela Filipová,Pavla Bojarová,Pavla Bojarová,Marina Rodrigues Tavares,Ladislav Bumba,Lothar Elling,Petr Chytil,Kristýna Gunár,Vladimír Křen,Tomáš Etrych,Olga Janoušková +10 more
TL;DR: The strong inhibitory activity toward Gal-3, combined with favorable pharmacokinetics of HPMA copolymers ensuring enhanced tumor accumulation via the enhanced permeability and retention effect, nominate the glycopolymers containing LacdiNAc-LacNAc (GalNAc β4GlcNAcβ3Galβ4GlCNAc) tetrasaccharide as promising tools for preclinical in anti-cancer therapy evaluation.
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Immunoprotective neo-glycoproteins: Chemoenzymatic synthesis of multivalent glycomimetics for inhibition of cancer-related galectin-3.
Viktoria Heine,Michaela Hovorková,Miluše Vlachová,Marcela Filipová,Ladislav Bumba,Olga Janoušková,Martin Hubálek,Josef Cvačka,Lucie Petrásková,Helena Pelantová,Vladimír Křen,Lothar Elling,Pavla Bojarová +12 more
TL;DR: In this article, a new chemoenzymatic method was established to produce selective C-3-substituted N,N′-diacetyllactosamine glycomimetics and coupled them to human serum albumin.
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Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography.
Oleksandr Shapoval,Viktoriia Oleksa,Miroslav Šlouf,Volodymyr Lobaz,Olga Trhlíková,Marcela Filipová,Olga Janoušková,Hana Engstová,Jan Pankrác,Adam Modrý,Vít Herynek,Petr Ježek,Luděk Šefc,Daniel Horák +13 more
TL;DR: In this article, hydrophilic poly(N,N-dimethylacrylamide-N-acryloylglycine methyl ester)-alendronate-[P(DMA-AGME)-Ale]-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+) nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) followed by coating with the polymer.