J
Joerg C. Schefold
Researcher at University of Bern
Publications - 237
Citations - 7470
Joerg C. Schefold is an academic researcher from University of Bern. The author has contributed to research in topics: Medicine & Intensive care unit. The author has an hindex of 38, co-authored 194 publications receiving 4931 citations. Previous affiliations of Joerg C. Schefold include Charité & Free University of Berlin.
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Journal ArticleDOI
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial.
Christian Meisel,Joerg C. Schefold,Rene Pschowski,Tycho Baumann,Katrin Hetzger,Jan Gregor,Steffen Weber-Carstens,Dietrich Hasper,Didier Keh,H. Zuckermann,Petra Reinke,Hans-Dieter Volk +11 more
TL;DR: Biomarker-guided GM-CSF therapy in sepsis is safe and effective for restoring monocytic immunocompetence and may shorten the time of mechanical ventilation and hospital/intensive care unit stay.
Journal ArticleDOI
Heart failure and kidney dysfunction: epidemiology, mechanisms and management
TL;DR: Important crosstalk between the heart and kidney is described, with a focus on HF and kidney disease in the acute and chronic settings, and underlying molecular and cellular pathomechanisms in HF, AKI and CKD are discussed in addition to current and future therapeutic approaches.
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The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity.
Marcin F. Osuchowski,Martin Sebastian Winkler,Tomasz Skirecki,Sara Cajander,Manu Shankar-Hari,Manu Shankar-Hari,Gunnar Lachmann,Guillaume Monneret,Fabienne Venet,Michael Bauer,Frank M. Brunkhorst,Sebastian Weis,Alberto García-Salido,Matthijs Kox,Jean-Marc Cavaillon,Florian Uhle,Markus A. Weigand,Stefanie B. Flohé,W. Joost Wiersinga,Raquel Almansa,Amanda de la Fuente,Ignacio Martin-Loeches,Christian Meisel,Thibaud Spinetti,Joerg C. Schefold,Catia Cilloniz,Antoni Torres,Antoni Torres,Evangelos J. Giamarellos-Bourboulis,Ricard Ferrer,Ricard Ferrer,Massimo Girardis,Andrea Cossarizza,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Tom van der Poll,Jesus F. Bermejo-Martin,Ignacio Rubio +38 more
TL;DR: The authors reviewed the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels.
Journal ArticleDOI
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms
Joerg C. Schefold,Jan-Philip Zeden,Christina Fotopoulou,Stephan von Haehling,Rene Pschowski,Dietrich Hasper,Hans-Dieter Volk,Christine Schuett,Petra Reinke +8 more
TL;DR: IDO activity and serum levels of tryptophan catabolites of the kynurenine pathway increase with CKD severity, and induction of IDO may primarily be a consequence of chronic inflammation.
Journal ArticleDOI
The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study
Bertrand Guidet,Dylan W. de Lange,Ariane Boumendil,Susannah Leaver,Ximena Watson,Carol Boulanger,Wojciech Szczeklik,Antonio Artigas,Alessandro Morandi,Finn H. Andersen,Tilemachos Zafeiridis,Christian Jung,Rui Moreno,Sten Walther,Sandra Oeyen,Joerg C. Schefold,Maurizio Cecconi,Brian Marsh,Michael Joannidis,Yuriy Nalapko,Muhammed Elhadi,Jesper Fjølner,Hans Flaatten,Hans Flaatten +23 more
TL;DR: It is confirmed that frailty assessment using the CFS is able to predict short-term mortality in elderly patients admitted to ICU, and should be routinely collected for all elderly ICU patients in particular in connection to advance care plans.