M
Michael Dworzak
Researcher at Medical University of Vienna
Publications - 264
Citations - 11553
Michael Dworzak is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Leukemia & Minimal residual disease. The author has an hindex of 54, co-authored 247 publications receiving 9775 citations. Previous affiliations of Michael Dworzak include Boston Children's Hospital & Community College of Rhode Island.
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Journal ArticleDOI
The MLL recombinome of acute leukemias in 2017
Christian Meyer,Thomas Burmeister,Daniela Gröger,Grigory Tsaur,L Fechina,Aline Renneville,Rosemary Sutton,Nicola C. Venn,Mariana Emerenciano,Maria S. Pombo-de-Oliveira,C Barbieri Blunck,B Almeida Lopes,Jan Zuna,Jan Trka,Paola Ballerini,Hélène Lapillonne,M. De Braekeleer,Giovanni Cazzaniga,L Corral Abascal,V H J van der Velden,Eric Delabesse,T S Park,S H Oh,Maria Luiza Macedo Silva,T Lund-Aho,Vesa Juvonen,Andrew S. Moore,Olaf Heidenreich,Josef Vormoor,Elena Zerkalenkova,Yulia Olshanskaya,Clara Bueno,Clara Bueno,Pablo Menendez,Pablo Menendez,Andrea Teigler-Schlegel,U zur Stadt,Jana Lentes,Gudrun Göhring,Anatoly Kustanovich,Olga Aleinikova,Beat W. Schäfer,S Kubetzko,Hans O. Madsen,Bernd Gruhn,X Duarte,Paula Gameiro,Eric Lippert,A Bidet,J M Cayuela,Emmanuelle Clappier,Cristina N. Alonso,Christian M. Zwaan,M M van den Heuvel-Eibrink,Shai Izraeli,Shai Izraeli,L. Trakhtenbrot,L. Trakhtenbrot,P Archer,Jeremy Hancock,Anja Möricke,Julia Alten,Martin Schrappe,Martin Stanulla,Sabine Strehl,Andishe Attarbaschi,Michael Dworzak,Oskar A. Haas,Renate Panzer-Grümayer,Lukasz Sedek,Tomasz Szczepański,Aurélie Caye,L Suarez,Hélène Cavé,Rolf Marschalek +74 more
TL;DR: This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.
Journal ArticleDOI
Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel.
Ursula Creutzig,Marry M. van den Heuvel-Eibrink,Brenda Gibson,Michael Dworzak,Souichi Adachi,Eveline S. J. M. de Bont,Jochen Harbott,Henrik Hasle,Donna L. Johnston,Akitoshi Kinoshita,Thomas Lehrnbecher,Guy Leverger,Ester Mejstrikova,Soheil Meshinchi,Andrea Pession,Susana C. Raimondi,Lillian Sung,Jan Stary,Christian M. Zwaan,Gertjan J.L. Kaspers,Dirk Reinhardt +20 more
TL;DR: In this article, the authors discuss differences between childhood and adult acute myeloid leukemia (AML) and highlight recommendations that are specific to children, as well as the particular relevance of new diagnostic and prognostic molecular markers in pediatric AML.
Journal ArticleDOI
The MLL recombinome of acute leukemias in 2013
Claus Meyer,Julia Hofmann,Thomas Burmeister,Daniela Gröger,T S Park,Mariana Emerenciano,M. Pombo De Oliveira,Aline Renneville,Patrick Villarese,Elizabeth Macintyre,Hélène Cavé,Emmanuelle Clappier,K. Mass-Malo,Jan Zuna,Jan Trka,E De Braekeleer,M. De Braekeleer,S H Oh,Grigory Tsaur,L Fechina,V H J van der Velden,J J M van Dongen,Eric Delabesse,Renata Binato,Mara Silva,AM Kustanovich,Olga V. Aleinikova,Marian H. Harris,T Lund-Aho,Vesa Juvonen,Olaf Heidenreich,Josef Vormoor,William W.L. Choi,Marie Jarošová,A. Kolenova,Clara Bueno,Pablo Menendez,S. Wehner,Cornelia Eckert,Pascaline Talmant,Sylvie Tondeur,Eric Lippert,E. Launay,Catherine Henry,Paola Ballerini,H. Lapillone,Mary Callanan,Jean Michel Cayuela,Charles Herbaux,Giovanni Cazzaniga,P. M. Kakadiya,Stefan K. Bohlander,Martina Ahlmann,Jong Rak Choi,Paula Gameiro,Dongsoon Lee,Juergen Krauter,Pascale Cornillet-Lefebvre,G te Kronnie,Beat W. Schäfer,S. Kubetzko,Cristina N. Alonso,U. Zur Stadt,Rosemary Sutton,N. C. Venn,Shai Izraeli,Luba Trakhtenbrot,H. O. Madsen,P. Archer,Jeremy Hancock,Nuno Cerveira,Manuel R. Teixeira,L Lo Nigro,Anja Möricke,Martin Stanulla,Martin Schrappe,Lukasz Sedek,Tomasz Szczepański,Christian M. Zwaan,Eva A. Coenen,M.M. van den Heuvel-Eibrink,Sabine Strehl,Michael Dworzak,Renate Panzer-Grümayer,Theodor Dingermann,Thomas Klingebiel,Rolf Marschalek +86 more
TL;DR: Long-distance inverse-polymerase chain reaction was used to characterize the chromosomal rearrangement of individual acute leukemia patients and revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level.
Journal ArticleDOI
Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study
Martin Schrappe,Maria Grazia Valsecchi,Claus R. Bartram,André Schrauder,Renate Panzer-Grümayer,Anja Möricke,Rosanna Parasole,Martin Zimmermann,Michael Dworzak,Barbara Buldini,Alfred Reiter,Giuseppe Basso,T. Klingebiel,Chiara Messina,Richard Ratei,Giovanni Cazzaniga,Rolf Koehler,Franco Locatelli,Beat W. Schäfer,Maurizio Aricò,Karl Welte,Jacques J.M. van Dongen,Helmut Gadner,Andrea Biondi,Valentino Conter +24 more
TL;DR: MRD ≥ 10(-3) at TP2 constitutes the most important predictive factor for relapse in childhood T-ALL, and an excellent outcome was obtained in 32% of patients turning MRD negative only at TP1, indicating that early (TP1) MRD levels were irrelevant if MRD at TP 2 was negative.
Journal ArticleDOI
Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.
Brian V. Balgobind,Susana C. Raimondi,Susana C. Raimondi,Jochen Harbott,Martin Zimmermann,Todd A. Alonzo,Anne Auvrignon,H. Berna Beverloo,Myron Chang,Ursula Creutzig,Michael Dworzak,Erik Forestier,Brenda Gibson,Henrik Hasle,Christine J. Harrison,Nyla A. Heerema,Nyla A. Heerema,Gertjan J.L. Kaspers,Anna Leszl,Nathalia Litvinko,Luca Lo Nigro,Akira Morimoto,Christine Perot,Rob Pieters,Dirk Reinhardt,Jeffrey E. Rubnitz,Franklin O. Smith,Franklin O. Smith,Jan Stary,Irina Stasevich,Sabine Strehl,Takashi Taga,Daisuke Tomizawa,David Webb,Zuzana Zemanova,C. Michel Zwaan,Marry M. van den Heuvel-Eibrink +36 more
TL;DR: Large differences in outcome within 11q23/MLL-rearranged pediatric AML and novel subgroups based on translocation partners that independently predict clinical outcome are identified.