M
Marcia B. Goldberg
Researcher at Harvard University
Publications - 132
Citations - 7365
Marcia B. Goldberg is an academic researcher from Harvard University. The author has contributed to research in topics: Shigella flexneri & Bacterial outer membrane. The author has an hindex of 41, co-authored 118 publications receiving 5732 citations. Previous affiliations of Marcia B. Goldberg include Pasteur Institute & Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.
Ellen Shrock,Ellen Shrock,Eric Fujimura,Eric Fujimura,Tomasz Kula,Tomasz Kula,Richard T. Timms,Richard T. Timms,I-Hsiu Lee,Yumei Leng,Yumei Leng,Matthew L Robinson,Brandon M. Sie,Brandon M. Sie,Mamie Z. Li,Mamie Z. Li,Yuezhou Chen,Jennifer K. Logue,Adam Zuiani,Denise J. McCulloch,Felipe J.N. Lelis,Stephanie A. Henson,Daniel R. Monaco,Meghan Travers,Shaghayegh Habibi,William Clarke,Patrizio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Alicja Piechocka-Trocha,Jonathan Z. Li,Ashok Khatri,Helen Y. Chu,Alexandra-Chloé Villani,Kyle R. Kays,Marcia B. Goldberg,Nir Hacohen,Michael R. Filbin,Xu G. Yu,Bruce D. Walker,Bruce D. Walker,Duane R. Wesemann,H. Benjamin Larman,James A. Lederer,Stephen J. Elledge,Stephen J. Elledge +45 more
TL;DR: A systematic characterization of the humoral response to severe acute respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed, important for understanding the immunogenicity of the viral proteome and the basis for cross-reactivity with the common-cold coronaviruses.
Journal ArticleDOI
Complete Genome Sequence and Comparative Genomics of Shigella flexneri Serotype 2a Strain 2457T
J. Wei,Marcia B. Goldberg,Valerie Burland,Malabi M. Venkatesan,W. Deng,Gregory P. Fournier,George F. Mayhew,Guy Plunkett,Debra J. Rose,Aaron E. Darling,Bob Mau,Nicole T. Perna,Shelley M. Payne,L. J. Runyen-Janecky,Shiguo Zhou,David C. Schwartz,Frederick R. Blattner +16 more
TL;DR: The complete genome sequence of Shigella flexneri serotype 2a strain 2457T (4,599,354 bp) was determined and it was found that the strain is distinctive in its large complement of insertion sequences, with several genomic rearrangements mediated by insertion sequences.
Journal ArticleDOI
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
Scott B. Snapper,Scott B. Snapper,Fuminao Takeshima,Inés M. Antón,Inés M. Antón,Ching-Hui Liu,Ching-Hui Liu,Sheila M. Thomas,Sheila M. Thomas,Deanna Nguyen,Darryll D. Dudley,Hunter B. Fraser,Daniel L. Purich,Marco Lopez-Ilasaca,Christoph Klein,Christoph Klein,Laurie Davidson,Roderick T. Bronson,Richard C. Mulligan,Richard C. Mulligan,Frederick S. Southwick,Raif S. Geha,Raif S. Geha,Marcia B. Goldberg,Fred S. Rosen,Fred S. Rosen,John H. Hartwig,John H. Hartwig,Frederick W. Alt,Frederick W. Alt,Frederick W. Alt +30 more
TL;DR: A crucial and non-redundant role for N-WASP in murine embryogenesis and in the actin-based motility of certain pathogens but not in the general formation of actin -containing structures is implied.
Journal ArticleDOI
Unipolar localization and atpase activity of icsa, a shigella flexneri protein involved in intracellular movement
TL;DR: IcsA, an S. flexneri protein involved in this movement, was purified and studied in vitro as mentioned in this paper, and the surface localization of IcsA on both extracellular and intracellular shigellae was unipolar.
Journal ArticleDOI
Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility.
TL;DR: It is demonstrated that stable expression of IcsA on the surface of Escherichia coli is sufficient to allow actin-dependent movement of E. coli in cytoplasmic extracts, at rates comparable to the movement of S. flexneri in infected cells.