Marco Mineo

TL;DR: The inhibitory effect of dasatinib on exosome production and vascular differentiation and signaling reveals a key role for Src in both the leukemia and its microenvironment.

TL;DR: Results showed how extracellular vesicle signaling promotes the malignant character of glioblastoma and how ectopic expression of miR-1 can mitigate this character, with possible implications for how to develop a unique miRNA-based therapy for gliOBlastoma management.

TL;DR: It is demonstrated that HIF1A-AS2 contributes to GSCs' speciation and adaptation to hypoxia within the tumor microenvironment, acting directly through its interactome and targets and indirectly by modulating responses to hypoxic stress depending on the subtype-specific genetic context.

TL;DR: It is concluded that also astrocytes in culture shed extracellular vesicles that contain the same angiogenic factors, as well as beta1-integrin, a membrane protein that is considered a marker of shedding.

TL;DR: Evidence is gained that neurons produce both vascular endothelial growth factor and fibroblast growth factor 2, two well‐known angiogenic factors, and that both factors are released by neurons, at least in part, by shedding of extracellular vesicles that contain β1 integrin, a membrane protein already known to be part of ExtracellularVesicles released by tumour cells.