M
Marcos H. de Moraes
Researcher at University of Washington
Publications - 14
Citations - 616
Marcos H. de Moraes is an academic researcher from University of Washington. The author has contributed to research in topics: Salmonella & Salmonella enterica. The author has an hindex of 8, co-authored 13 publications receiving 387 citations. Previous affiliations of Marcos H. de Moraes include University of Florida & State University of Campinas.
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Journal ArticleDOI
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
Beverly Mok,Beverly Mok,Beverly Mok,Marcos H. de Moraes,Jun Zeng,Dustin E Bosch,Anna V. Kotrys,Anna V. Kotrys,Anna V. Kotrys,Aditya Raguram,Aditya Raguram,Aditya Raguram,FoSheng Hsu,Matthew C. Radey,S. Brook Peterson,Vamsi K. Mootha,Vamsi K. Mootha,Joseph D. Mougous,David R. Liu,David R. Liu,David R. Liu +20 more
TL;DR: An interbacterial toxin that catalyses the deamination of cytidines within double-stranded DNA forms part of a CRISPR-free, RNA-free base editing system that enables manipulation of human mitochondrial DNA.
Journal ArticleDOI
A genome survey of Moniliophthora perniciosa gives new insights into Witches' Broom Disease of cacao
Jorge Maurício Costa Mondego,Marcelo Falsarella Carazzolle,Gustavo G.L. Costa,Eduardo Fernandes Formighieri,Lucas Pedersen Parizzi,Johana Rincones,Carolina Cotomacci,Dirce Maria Carraro,Anderson F. Cunha,Helaine Carrer,Ramon O. Vidal,Raissa Estrela,Odalys Garcia,Daniela P. T. Thomazella,Bruno V. de Oliveira,Acassia Benjamin Leal Pires,Maria Carolina Scatolin do Rio,Marcos Renato R. Araújo,Marcos H. de Moraes,Luis As Castro,Karina Peres Gramacho,Marilda Souza Goncalves,José Pereira de Moura Neto,Aristóteles Góes Neto,Luciana Veiga Barbosa,Mark J. Guiltinan,Bryan A. Bailey,Lyndel W. Meinhardt,J.C.M. Cascardo,Gonçalo A.G. Pereira +29 more
TL;DR: A significant portion of the M. perniciosa genome is involved in stress adaptation and plant necrosis, two necessary characteristics for a hemibiotrophic fungus to fulfill its infection cycle.
Journal ArticleDOI
Salmonella Persistence in Tomatoes Requires a Distinct Set of Metabolic Functions Identified by Transposon Insertion Sequencing.
Marcos H. de Moraes,Prerak T. Desai,Steffen Porwollik,Rocío Canals,Daniel R. Perez,Weiping Chu,Michael McClelland,Max Teplitski +7 more
TL;DR: Overall, however, it appears that while Salmonella shares some strategies with phytopathogens and taps into its animal virulence-related functions, colonization of tomatoes represents a distinct strategy, highlighting this pathogen's flexible metabolism.
Journal ArticleDOI
Production of the Plant Hormone Auxin by Salmonella and Its Role in the Interactions with Plants and Animals.
Clayton E. Cox,Maria T. Brandl,Marcos H. de Moraes,Sarath P. Gunasekera,Max Teplitski,Max Teplitski +5 more
TL;DR: Orthologs of ipdC are found in all Salmonella genomes and are distributed among many animal pathogens and plant-associated bacteria of the Enterobacteriaceae, suggesting a broad ecological role of the IpdC-catalyzed pathway.
Journal ArticleDOI
An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations.
Marcos H. de Moraes,FoSheng Hsu,Dean Huang,Dustin E Bosch,Jun Zeng,Matthew C. Radey,Noah Simon,Hannah E. Ledvina,Jacob P Frick,Paul A. Wiggins,S. Brook Peterson,Joseph D. Mougous +11 more
TL;DR: The effects of intoxication by DddA, a cytosine deaminase delivered via the type VI secretion system of Burkholderia cenocepacia, are examined, indicating that even in the absence of killing, interbacterial toxins can have profound consequences on target populations.