Anna V. Kotrys

TL;DR: MitoCarta3.0, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome, is introduced and includes manually curated annotations of sub-mitochondrial localization and MitoPathway annotations, spanning seven broad functional categories relevant to mitochondria.

TL;DR: An interbacterial toxin that catalyses the deamination of cytidines within double-stranded DNA forms part of a CRISPR-free, RNA-free base editing system that enables manipulation of human mitochondrial DNA.

TL;DR: A fluorescent biosensor based on dual-color, single-molecule RNA imaging that allows intact transcripts to be distinguished from stabilized degradation intermediates is developed and shows that slicing of an mRNA targeted for endonucleolytic cleavage by the RNA-induced silencing complex can be observed in real time in living cells.

TL;DR: In this article , the authors used phage-assisted non-continuous and continuous evolution to evolve DddA variants with improved activity and expanded targeting scope, which substantially increase the effectiveness and applicability of all-protein base editing.

TL;DR: The complex turnover of mitochondrial transcripts is summarized and an increasing body of evidence indicating new functions of mitochondria transcripts is presented, highlighting the importance of emerging aspects of mitochondrial gene regulation in human health and disease.