M
Marek J. Łos
Researcher at Silesian University of Technology
Publications - 58
Citations - 2755
Marek J. Łos is an academic researcher from Silesian University of Technology. The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 21, co-authored 50 publications receiving 2096 citations. Previous affiliations of Marek J. Łos include Laboratory of Molecular Biology & Medical University of Silesia.
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Journal ArticleDOI
Autophagy and apoptosis dysfunction in neurodegenerative disorders.
Saeid Ghavami,Shahla Shojaei,Behzad Yeganeh,Sudharsana R. Ande,Jaganmohan Reddy Jangamreddy,Maryam Mehrpour,Jonas Christoffersson,Wiem Chaabane,Adel Rezaei Moghadam,Hessam H. Kashani,Mohammad Hashemi,Ali Akbar Owji,Marek J. Łos +12 more
TL;DR: In this article, the authors provide a brief introduction to autophagy and apoptosis pathways focusing on the role of mitochondria and lysosomes, and discuss different ways that autophag and apoptotic modulation may be employed for therapeutic intervention during the maintenance of neurodegenerative disorders.
Journal ArticleDOI
Interconnections between apoptotic, autophagic and necrotic pathways : implications for cancer therapy development
Mayur V. Jain,Anna M. Paczulla,Thomas Klonisch,Florence N. Dimgba,Sahana B. Rao,Karin Roberg,Frank Schweizer,Claudia Lengerke,Padideh Davoodpour,Vivek Reddy Palicharla,Subbareddy Maddika,Marek J. Łos +11 more
TL;DR: This review extends the analysis of cell death beyond apoptosis to include signalling pathways governing autophagy and necrosis and highlights stress‐induced cell senescence that plays a role not only in organismal ageing but also offers the development of novel anticancer strategies.
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Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells☆
Jaganmohan Reddy Jangamreddy,Saeid Ghavami,Jerzy Grabarek,Gunnar Kratz,Emilia Wiechec,Bengt-Arne Fredriksson,Rama Krishna Rao Pariti,Artur Cieślar-Pobuda,Artur Cieślar-Pobuda,Soumya Panigrahi,Marek J. Łos,Marek J. Łos +11 more
TL;DR: A massive autophagic response to Salinomycin is shown (substantially stronger than to commonly used Autophagic inducer Rapamycin) in prostrate-, breast cancer cells, and to lesser degree in human normal dermal fibroblasts, and new insight is provided into the molecular mechanism of preferential toxicity of SalInomycin towards cancer cells.
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New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets
Pooneh Mokarram,Mohammed Albokashy,Maryam Zarghooni,Mohammad Amin Moosavi,Zahra Sepehri,Qi Min Chen,Andrzej Hudecki,Aliyeh Sargazi,Javad Alizadeh,Adel Rezaei Moghadam,Mohammad Hashemi,Hesam Movassagh,Thomas Klonisch,Ali Akbar Owji,Marek J. Łos,Saeid Ghavami +15 more
TL;DR: This review addresses the epidemiology and risk factors of CRC, including genetic mutations leading to the occurrence of the disease and how autophagy and the UPR are involved in the regulation of CRC and how they associate with obesity and inflammatory responses in CRC.
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FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy.
Sylwester Drożdżal,Jakub Rosik,Kacper Lechowicz,Filip Machaj,Katarzyna Kotfis,Saeid Ghavami,Marek J. Łos +6 more
TL;DR: The initial results of a number of clinical trials involving various protocols of administration of chloroquine or hydroxychloroquine mostly point towards their beneficial effect, but they may not be effective in cases with persistently high viremia, while results on ivermectin (another antiparasitic agent) are not yet available.