A
Adel Rezaei Moghadam
Researcher at University of Manitoba
Publications - 18
Citations - 1630
Adel Rezaei Moghadam is an academic researcher from University of Manitoba. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 14, co-authored 18 publications receiving 1320 citations. Previous affiliations of Adel Rezaei Moghadam include University of Toronto & Islamic Azad University.
Papers
More filters
Journal ArticleDOI
Autophagy and apoptosis dysfunction in neurodegenerative disorders.
Saeid Ghavami,Shahla Shojaei,Behzad Yeganeh,Sudharsana R. Ande,Jaganmohan Reddy Jangamreddy,Maryam Mehrpour,Jonas Christoffersson,Wiem Chaabane,Adel Rezaei Moghadam,Hessam H. Kashani,Mohammad Hashemi,Ali Akbar Owji,Marek J. Łos +12 more
TL;DR: In this article, the authors provide a brief introduction to autophagy and apoptosis pathways focusing on the role of mitochondria and lysosomes, and discuss different ways that autophag and apoptotic modulation may be employed for therapeutic intervention during the maintenance of neurodegenerative disorders.
Journal ArticleDOI
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Behzad Yeganeh,Emmilia Wiechec,Sudharsana R. Ande,Pawan K. Sharma,Adel Rezaei Moghadam,Martin Post,Darren H. Freed,Mohammad Hashemi,Shahla Shojaei,Amir A. Zeki,Saeid Ghavami +10 more
TL;DR: This review will focus on the therapeutic applications and mechanisms involved in the MVA cascade including Rho GTPase and Rho kinase (ROCK) signaling, statin inhibition of HMGCR, geranylgeranyltransferase (GGTase) inhibition, and farnesyl transferase (FTase) inhibited in cardiovascular disease, pulmonary diseases, and cancer.
Journal ArticleDOI
New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets
Pooneh Mokarram,Mohammed Albokashy,Maryam Zarghooni,Mohammad Amin Moosavi,Zahra Sepehri,Qi Min Chen,Andrzej Hudecki,Aliyeh Sargazi,Javad Alizadeh,Adel Rezaei Moghadam,Mohammad Hashemi,Hesam Movassagh,Thomas Klonisch,Ali Akbar Owji,Marek J. Łos,Saeid Ghavami +15 more
TL;DR: This review addresses the epidemiology and risk factors of CRC, including genetic mutations leading to the occurrence of the disease and how autophagy and the UPR are involved in the regulation of CRC and how they associate with obesity and inflammatory responses in CRC.
Journal ArticleDOI
Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts
Saeid Ghavami,Saeid Ghavami,Behzad Yeganeh,Amir A. Zeki,Shahla Shojaei,Nicholas J. Kenyon,Sean Ott,Afshin Samali,John B. Patterson,Javad Alizadeh,Javad Alizadeh,Adel Rezaei Moghadam,Adel Rezaei Moghadam,Ian M.C. Dixon,Helmut Unruh,Darryl A. Knight,Martin Post,Thomas Klonisch,Andrew J. Halayko,Andrew J. Halayko +19 more
TL;DR: The IRE1 arm of the UPR response is uniquely induced by TGF-β1 in lung fibroblasts from human IPF donors and is required for excessive biosynthesis of collagen and fibronectin in these cells.
Journal ArticleDOI
Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.
Javad Alizadeh,Amir A. Zeki,Nima Mirzaei,Sandipan Tewary,Adel Rezaei Moghadam,Aleksandra Glogowska,Pandian Nagakannan,Eftekhar Eftekharpour,Emilia Wiechec,Joseph W. Gordon,Fred Y. Xu,Jared T. Field,Ken Y. Yoneda,Nicholas J. Kenyon,Mohammad Hashemi,Grant M. Hatch,Sabine Hombach-Klonisch,Thomas Klonisch,Saeid Ghavami,Saeid Ghavami +19 more
TL;DR: The results indicate that MEV cascade inhibition by simvastatin induced the intrinsic apoptosis pathway via inhibition of Rho family prenylation and depletion of GGPP, in a variety of different human cancer cell lines.