M
Margarita Del Val
Researcher at Spanish National Research Council
Publications - 52
Citations - 2196
Margarita Del Val is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: MHC class I & Antigen. The author has an hindex of 21, co-authored 50 publications receiving 2006 citations. Previous affiliations of Margarita Del Val include University of Ulm & Carlos III Health Institute.
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Journal ArticleDOI
Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.
Loredana Saveanu,Oliver Carroll,Vivian Lindo,Margarita Del Val,Daniel López,Yves Lepelletier,Fiona M. Greer,Lutz Schomburg,Doriana Fruci,Gabriele Niedermann,Peter van Endert +10 more
TL;DR: The human endoplasmic reticulum is equipped with a pair of trimming aminopeptidases that have complementary functions in HLA class I peptide presentation, and it is shown here that one of these, ERAP1, was unable to remove several N-terminal amino acids that were trimmed efficiently by the second enzyme.
Journal ArticleDOI
Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein.
TL;DR: It is documented that not only the sequence of the presented peptide but also the residues by which it is flanked in the protein determine the efficiency of processing and presentation.
Journal ArticleDOI
Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5
Maria Buxadé,Giulia Lunazzi,Jorge Minguillón,Salvador Iborra,Rosa Berga-Bolaños,Margarita Del Val,Margarita Del Val,Jorge Aramburu,Cristina López-Rodríguez +8 more
TL;DR: NFAT5 regulates the induction ofTLR-stimulated genes with constitutive binding to the Tnf promoter regardless of TLR ligation and recruitment to Nos2 and Il6 dependent on TLR activation and IKKb.
Molecular BasisforCytolytic T-Lymphocyte Recognition ofthe MurineCytomegalovirus Immediate-Early Protein pp89
TL;DR: A region of only one-sixth of the protein, from amino acids 154 to 249 and encoded by the fourth exon of gene ieI, was sufficient for both the recognition in vitro of theprotein by pp89-specific cytotoxic T lymphocytes and the induction in vivo of pp 89-specific cytolytic T lymphocyte.
Journal ArticleDOI
Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase.
TL;DR: The regulation of antigen processing and presentation to MHC class I-restricted cytolytic T lymphocytes was studied in cells infected with murine cytomegalovirus and failure in recognition indicates a selective interference with pp89 antigenprocessing and presentation.