Maria B. Carreira

TL;DR: The findings reveal a molecular mechanism by which cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, likely by putting a brake on drug-stimulated gene expression that supports drug-induced behavioral changes.

TL;DR: It is found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model and that nuclear HDAC5 limits reinstatement of drug seeking independent of NPAS4.

TL;DR: Results show that sex differences in fear behaviors following foreground contextual conditioning depend on the phase of the estrous cycle, and males expressed higher levels in all brain regions examined compared to females.

TL;DR: In females anxiety- and depression-like behaviors explained a large part of the variance observed across tests in the authors' battery, whereas male behavior was primarily explained by variables related to locomotion.

TL;DR: Depressive symptoms, limitations in Instrumental Activities of Daily Living, IL-7 and I-309 were significantly related to fall events, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.