HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.
Makoto Taniguchi,Maria B. Carreira,Yonatan A. Cooper,Ana-Clara Bobadilla,Jasper A. Heinsbroek,Nobuya Koike,Erin B. Larson,Evan A. Balmuth,Brandon W. Hughes,Rachel D. Penrod,Rachel D. Penrod,Jaswinder Kumar,Jaswinder Kumar,Laura N. Smith,Daniel Guzman,Joseph S. Takahashi,Tae Kyung Kim,Peter W. Kalivas,David W. Self,Yingxi Lin,Christopher W. Cowan,Christopher W. Cowan +21 more
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TLDR
It is found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model and that nuclear HDAC5 limits reinstatement of drug seeking independent of NPAS4.About:
This article is published in Neuron.The article was published on 2017-09-27 and is currently open access. It has received 82 citations till now. The article focuses on the topics: Epigenetics of cocaine addiction & Conditioned place preference.read more
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Different Neuronal Activity Patterns Induce Different Gene Expression Programs
Kelsey M. Tyssowski,Nicholas R. DeStefino,Jin-Hyung Cho,Carissa J. Dunn,Robert G. Poston,Crista Carty,Richard D. Jones,Sarah M. Chang,Palmyra Romeo,Mary K. Wurzelmann,James M. Ward,Mark L. Andermann,Ramendra N. Saha,Ramendra N. Saha,Serena M. Dudek,Jesse M. Gray +15 more
TL;DR: The same mechanisms that establish the multi-wave temporal structure of gene induction also enable different gene sets to be induced by different activity durations and improve the understanding of activity-pattern-dependent synaptic plasticity.
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A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell
TL;DR: The anatomical-functional backdrop upon which several neuropeptides act within the NAc to modulate behavior is described, with a specific emphasis on nucleus accumbens medial shell and stress responsivity.
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How the epigenome integrates information and reshapes the synapse.
TL;DR: An overview of key established epigenetic mechanisms that are important for memory formation is provided, with a particular focus on the bidirectional relationship between the epigenome and the synapse.
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Overexpression of the histone dimethyltransferase G9a in nucleus accumbens shell increases cocaine self-administration, stress-induced reinstatement, and anxiety
Ethan M. Anderson,Erin B. Larson,Daniel Guzman,Anne Marie Wissman,Rachael L. Neve,Eric J. Nestler,David W. Self +6 more
TL;DR: G9a, an epigenetic repressor of gene expression, acting in the nucleus accumbens, a brain reward region, is capable of increasing both addiction- and anxiety-like behaviors in rats and indicates a novel role for G9a in promoting comorbid cocaine addiction and anxiety.
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Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
Yong-Chuan Zhu,Min Huang,Eric A. Bushong,Sebastien Phan,Marco Uytiepo,Elizabeth Beutter,Daniel Boemer,Kristin Tsui,Mark H. Ellisman,Anton Maximov +9 more
TL;DR: A new mechanism is described that regulates the cellular patterns of early response gene signaling during learning via the recruitment of two functionally redundant nuclear repressors, class IIa histone deacetylases (HDACs) 4 and 5.
References
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