Maria Katsantoni

TL;DR: The prospect of integrating data obtained by CLIP with complementary methods to gain a comprehensive view of RNP assembly and remodelling, unravel the spatial and temporal dynamics of RNPs in specific cell types and subcellular compartments and understand how defects in RNPs can lead to disease are discussed.

TL;DR: An overview of S IB's resources and competence areas is provided, with a strong focus on curated databases and SIB's most popular and widely used resources.

TL;DR: In this article, the authors determined the structure of the RRM1 bound to RNA and found that the domain binds preferentially to a CN motif (N is for any nucleotide).

TL;DR: RCRUNCH as discussed by the authors is an end-to-end solution to CLIP data analysis for identification of binding sites and sequence specificity of RNA-binding proteins, which can analyze not only reads that map uniquely to the genome but also those that map to multiple genome locations or across splice boundaries and can consider various types of background in the estimation of read enrichment.

TL;DR: RCRUNCH as mentioned in this paper is an end-to-end solution to CLIP data analysis for identification of binding sites and sequence specificity of RNA-binding proteins, which can analyze not only reads that map uniquely to the genome, but also those that map to multiple genome locations or across splice boundaries, and can consider various types of background in the estimation of read enrichment.