M
Maria Li Lung
Researcher at University of Hong Kong
Publications - 226
Citations - 6356
Maria Li Lung is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Nasopharyngeal carcinoma & Cancer. The author has an hindex of 44, co-authored 208 publications receiving 5541 citations. Previous affiliations of Maria Li Lung include Shantou University & Cumhuriyet University.
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Journal ArticleDOI
Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma.
Hong Zheng,Wei Dai,Arthur Kwok Leung Cheung,Josephine Mun Yee Ko,Rebecca Kan,Bonnie W.Y. Wong,Merrin Man Long Leong,Mingdan Deng,Tommy Chin Tung Kwok,Jimmy Yu-Wai Chan,Dora L.W. Kwong,Anne Wing-Mui Lee,Wai Tong Ng,Roger Kai Cheong Ngan,Chun Chung Yau,Stewart Tung,Victor Ho-Fun Lee,Ka-On Lam,Chung Kong Kwan,Wing Sum Li,Stephen S.-T. Yau,Kwok Wah Chan,Maria Li Lung +22 more
TL;DR: Somatic mutations in NFKBIA leading to protein truncation contributed to the altered NF-κB activity, which is critical for NPC tumorigenesis, and somatic mutations were found in several cancer-relevant pathways, including cell cycle-phase transition, cell death, EBV infection, and viral carcinogenesis.
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A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
Kwan Ho Tang,Yong Dong Dai,Man Tong,Yuen Piu Chan,Pak Shing Kwan,Li Fu,Yan Ru Qin,Sai Wah Tsao,Hong Lok Lung,Maria Li Lung,Daniel K. Tong,Simon Law,Kwok Wah Chan,Stephanie Ma,Xin Yuan Guan +14 more
TL;DR: A CD90(+) cell population found in esophageal squamous cell carcinoma (ESCC), which is endowed with stem cell-like properties and high tumorigenic and metastatic potential, is reported.
Journal ArticleDOI
THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma
Hong Lok Lung,Dhinoth Kumar Bangarusamy,Dan Xie,Dan Xie,Arthur Kwok Leung Cheung,Yue Cheng,Mande K. Kumaran,Mande K. Kumaran,Lance D. Miller,Edison T. Liu,Xin Yuan Guan,Jonathan S.T. Sham,Yan Fang,Liqiong Li,Nancy Wang,A.I. Protopopov,Eugene R. Zabarovsky,Sai Wah Tsao,Eric J. Stanbridge,Maria Li Lung +19 more
TL;DR: THY1 is a good candidate tumour suppressor gene in NPC, which is significantly associated with lymph node metastases, according to clinical study and gene expression and protein analyses.
Journal ArticleDOI
Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells
Chi Man Tsang,Yim Ling Yip,Kwok Wai Lo,Wen Deng,Ka Fai To,Pok Man Hau,Victoria Ming Yi Lau,Kenzo Takada,Vivian Wai Yan Lui,Maria Li Lung,Honglin Chen,Mu Sheng Zeng,Jaap M. Middeldorp,Annie L.M. Cheung,Sai Wah Tsao +14 more
TL;DR: It is concluded that dysregulated expression of cyclin D1 in NPE cells may contribute to NPC pathogenesis by enabling persistent infection of EBV.
Journal ArticleDOI
Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas.
Hongchuan Jin,Xian Wang,Jianming Ying,Ada Ho Yan Wong,Hongyu Li,Kwan Yeung Lee,Gopesh Srivastava,Anthony T.C. Chan,Winnie Yeo,Brigette B.Y. Ma,Thomas C. Putti,Maria Li Lung,Zhong-Ying Shen,Li-Yan Xu,Cordelia Langford,Qian Tao +15 more
TL;DR: Through functional epigenetics, ADAMTS18 was identified as a novel functional tumor suppressor, being frequently inactivated epigenetically in multiple carcinomas.