D
Daniela Stan
Researcher at Romanian Academy
Publications - 25
Citations - 671
Daniela Stan is an academic researcher from Romanian Academy. The author has contributed to research in topics: Resistin & Chemokine. The author has an hindex of 16, co-authored 25 publications receiving 597 citations.
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Journal ArticleDOI
Similar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cells
Ileana Manduteanu,Monica Pirvulescu,Ana-Maria Gan,Daniela Stan,Viorel Simion,Elena Dragomir,Manuela Calin,Adrian Manea,Maya Simionescu +8 more
TL;DR: In HEC, resistin and HG induce the up-regulation of P-selectin and fractalkine and the ensuing increased monocyte adhesion by a mechanism involving oxidative stress and NF-kB and AP-1 activation.
Journal ArticleDOI
Cross talk between smooth muscle cells and monocytes/activated monocytes via CX3CL1/CX3CR1 axis augments expression of pro-atherogenic molecules.
Elena Butoi,Ana-Maria Gan,Ileana Manduteanu,Daniela Stan,Manuela Calin,Monica Pirvulescu,Rory R. Koenen,Christian Weber,Maya Simionescu +8 more
TL;DR: The cross-talk between SMC and monocytes augments the inflammatory response in both cell types as revealed by the increased expression of TNFα,IL-1β, IL-6, CX3CR1 and MMPs.
Journal ArticleDOI
Cross-talk between macrophages and smooth muscle cells impairs collagen and metalloprotease synthesis and promotes angiogenesis
Elena Butoi,Ana-Maria Gan,Monica Madalina Tucureanu,Daniela Stan,Razvan Daniel Macarie,Cristina Ana Constantinescu,Manuela Calin,Maya Simionescu,Ileana Manduteanu +8 more
TL;DR: MAC-SMC communication affects factors and molecules that could alter ECM composition and neo-angiogenesis, features that could directly dictate the progression of atheroma towards the vulnerable plaque.
Journal ArticleDOI
High glucose conditions induce upregulation of fractalkine and monocyte chemotactic protein-1 in human smooth muscle cells
Elena Dragomir,Ileana Manduteanu,Manuela Calin,Ana-Maria Gan,Daniela Stan,Rory R. Koenen,Christian Weber,Maya Simionescu +7 more
TL;DR: HG upregulates the expression of fractalkine and MCP-1 in SMC leading to increased monocyte-SMC adhesive interactions by a mechanism involving activation of MAPK, activator protein-1 (AP-1) and NF-kappaB.
Journal ArticleDOI
VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes.
Manuela Calin,Daniela Stan,Martin Schlesinger,Viorel Simion,Mariana Deleanu,Cristina Ana Constantinescu,Ana-Maria Gan,Monica Pirvulescu,Elena Butoi,Ileana Manduteanu,Marian Bota,Marius Enachescu,Lubor Borsig,Gerd Bendas,Maya Simionescu +14 more
TL;DR: It is reported that Vp-TSL-Tj binds specifically to activated EC in vitro and in situ, release the entrapped Teijin and prevent the transmigration of monocytes through activated EC, the first evidence that nanocarriers which transport and release chemokine inhibitors at specific pathological sites can reduceChemokine-dependent inflammatory processes.