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Elena Butoi
Researcher at Romanian Academy
Publications - 29
Citations - 686
Elena Butoi is an academic researcher from Romanian Academy. The author has contributed to research in topics: Chemokine & Monocyte. The author has an hindex of 13, co-authored 26 publications receiving 516 citations.
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Journal ArticleDOI
Contribution of Platelet CX 3 CR1 to Platelet–Monocyte Complex Formation and Vascular Recruitment During Hyperlipidemia
Otilia Postea,Elena M. Vasina,Sandra Cauwenberghs,Delia Projahn,Elisa A. Liehn,Dirk Lievens,Wendy Theelen,Birgit K. Kramp,Elena Butoi,Oliver Soehnlein,Johan W. M. Heemskerk,Andreas Ludwig,Christian Weber,Rory R. Koenen +13 more
TL;DR: A significant involvement of the CX3CL1–CX3CR1 axis in platelet accumulation and monocyte recruitment at sites of arterial injury in atherosclerosis is suggested.
Journal ArticleDOI
Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of G i -protein inhibitor
Monica Madalina Tucureanu,Daniela Rebleanu,Cristina Ana Constantinescu,Mariana Deleanu,Geanina Voicu,Elena Butoi,Manuela Calin,Ileana Manduteanu +7 more
TL;DR: The potential of liposomal GOT in blocking LPS proinflammatory effects in monocytes/macrophages is demonstrated and reduced monocyte adhesion and chemotaxis.
Journal ArticleDOI
Cross talk between smooth muscle cells and monocytes/activated monocytes via CX3CL1/CX3CR1 axis augments expression of pro-atherogenic molecules.
Elena Butoi,Ana-Maria Gan,Ileana Manduteanu,Daniela Stan,Manuela Calin,Monica Pirvulescu,Rory R. Koenen,Christian Weber,Maya Simionescu +8 more
TL;DR: The cross-talk between SMC and monocytes augments the inflammatory response in both cell types as revealed by the increased expression of TNFα,IL-1β, IL-6, CX3CR1 and MMPs.
Journal ArticleDOI
Cross-talk between macrophages and smooth muscle cells impairs collagen and metalloprotease synthesis and promotes angiogenesis
Elena Butoi,Ana-Maria Gan,Monica Madalina Tucureanu,Daniela Stan,Razvan Daniel Macarie,Cristina Ana Constantinescu,Manuela Calin,Maya Simionescu,Ileana Manduteanu +8 more
TL;DR: MAC-SMC communication affects factors and molecules that could alter ECM composition and neo-angiogenesis, features that could directly dictate the progression of atheroma towards the vulnerable plaque.
Journal ArticleDOI
VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes.
Manuela Calin,Daniela Stan,Martin Schlesinger,Viorel Simion,Mariana Deleanu,Cristina Ana Constantinescu,Ana-Maria Gan,Monica Pirvulescu,Elena Butoi,Ileana Manduteanu,Marian Bota,Marius Enachescu,Lubor Borsig,Gerd Bendas,Maya Simionescu +14 more
TL;DR: It is reported that Vp-TSL-Tj binds specifically to activated EC in vitro and in situ, release the entrapped Teijin and prevent the transmigration of monocytes through activated EC, the first evidence that nanocarriers which transport and release chemokine inhibitors at specific pathological sites can reduceChemokine-dependent inflammatory processes.