M
Marie-Hélène Seguelas
Researcher at French Institute of Health and Medical Research
Publications - 33
Citations - 2079
Marie-Hélène Seguelas is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Mesenchymal stem cell & Kidney. The author has an hindex of 19, co-authored 31 publications receiving 1891 citations. Previous affiliations of Marie-Hélène Seguelas include University of Toulouse.
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Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction.
Céline Mias,Céline Mias,Olivier Lairez,Olivier Lairez,Elodie Trouche,Elodie Trouche,Jerome Roncalli,Denis Calise,Marie-Hélène Seguelas,Catherine Ordener,Marie-Dominique Piercecchi-Marti,Nathalie Augé,Anne Negre Salvayre,Philippe Bourin,Angelo Parini,Angelo Parini,Daniel Cussac,Daniel Cussac +17 more
TL;DR: MSCs modulate the phenotype of cardiac fibroblasts and their ability to degrade extracellular matrix and these properties open new perspectives for understanding the mechanisms of action of MSCs and anticipate their potential therapeutic or side effects.
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Oxidative Stress by Monoamine Oxidase Mediates Receptor-Independent Cardiomyocyte Apoptosis by Serotonin and Postischemic Myocardial Injury
Pascale Bianchi,Oxana Kunduzova,Emanuela Masini,Claudie Cambon,Daniele Bani,Laura Raimondi,Marie-Hélène Seguelas,Silvia Nistri,Wilson S. Colucci,Nathalie Leducq,Angelo Parini +10 more
TL;DR: The results supply the first direct evidence that oxidative stress induced by MAO is responsible for receptor-independent apoptotic effects of 5-HT in cardiomyocytes and postischemic myocardial injury.
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Ex Vivo Pretreatment with Melatonin Improves Survival, Proangiogenic/Mitogenic Activity, and Efficiency of Mesenchymal Stem Cells Injected into Ischemic Kidney
Céline Mias,Elodie Trouche,Marie-Hélène Seguelas,Fabien Calcagno,Françoise Dignat-George,Florence Sabatier,Marie-Dominique Piercecchi-Marti,Laurent Daniel,Pascale Bianchi,Denis Calise,Philippe Bourin,Angelo Parini,Angelo Parini,Daniel Cussac,Daniel Cussac +14 more
TL;DR: A strategy of ex vivo pretreatment with the pineal hormone melatonin to improve survival, paracrine activity, and efficiency of bone marrow mesenchymal stem cells is designed.
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Oxidative Stress–Dependent Sphingosine Kinase-1 Inhibition Mediates Monoamine Oxidase A–Associated Cardiac Cell Apoptosis
Dimitri Pchejetski,Oxana Kunduzova,Audrey Dayon,Denis Calise,Marie-Hélène Seguelas,Nathalie Leducq,Isabelle Seif,Angelo Parini,Olivier Cuvillier +8 more
TL;DR: It is shown for the first time that the upregulation of ceramide/sphingosine 1-phosphate ratio is a critical event in MAO-A–mediated cardiac cell apoptosis and the first evidence linking generation of reactive oxygen species with SphK1 inhibition is provided.
Journal ArticleDOI
Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
Aude Saulière,Morgane Bellot,Hervé Paris,Colette Denis,Frédéric Finana,Jonas Tind Hansen,Marie-Françoise Altié,Marie-Hélène Seguelas,Atul Pathak,Jakob Lerche Hansen,Jean-Michel Senard,Céline Galés +11 more
TL;DR: New, highly sensitive and direct bioluminescence resonance energy transfer-based G protein activation probes specific for all G protein isoforms are developed and used to evaluate the G protein-coupling activity of angiotensin II, a biased agonist that may stabilize and create a new distinct active pharmacological receptor entity.