O
Olivier Lairez
Researcher at University of Toulouse
Publications - 240
Citations - 6875
Olivier Lairez is an academic researcher from University of Toulouse. The author has contributed to research in topics: Medicine & Heart failure. The author has an hindex of 33, co-authored 214 publications receiving 5037 citations. Previous affiliations of Olivier Lairez include Paul Sabatier University & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy
Christian Templin,Jelena R. Ghadri,Johanna Diekmann,L. Christian Napp,Dana Roxana Bataiosu,Milosz Jaguszewski,Victoria L. Cammann,Annahita Sarcon,Verena Geyer,Catharina A. Neumann,Burkhardt Seifert,Jens P. Hellermann,Moritz Schwyzer,Katharina Eisenhardt,Josef Jenewein,Jennifer Franke,Hugo A. Katus,Christof Burgdorf,Heribert Schunkert,Christian Moeller,Holger Thiele,Johann Bauersachs,Carsten Tschöpe,Heinz-Peter Schultheiss,Charles A. Laney,Lawrence Rajan,Guido Michels,Roman Pfister,Christian Ukena,Michael Böhm,Raimund Erbel,Alessandro Cuneo,Karl-Heinz Kuck,Claudius Jacobshagen,Gerd Hasenfuss,M. Karakas,M. Karakas,Wolfgang Koenig,Wolfgang Koenig,Wolfgang Rottbauer,Samir M. Said,Ruediger C. Braun-Dullaeus,Florim Cuculi,Adrian P. Banning,Thomas Fischer,Tuija Vasankari,K.E. Juhani Airaksinen,Marcin Fijałkowski,Andrzej Rynkiewicz,Maciej Pawlak,Grzegorz Opolski,Rafal Dworakowski,Philip MacCarthy,Christoph Kaiser,Stefan Osswald,Leonarda Galiuto,Filippo Crea,Wolfgang Dichtl,Wolfgang-Michael Franz,Klaus Empen,Stephan B. Felix,Clément Delmas,Olivier Lairez,Paul Erne,Jeroen J. Bax,Ian Ford,Frank Ruschitzka,Abhiram Prasad,Thomas F. Lüscher +68 more
TL;DR: Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome and physical triggers, acute neurologics or psychiatric diseases, high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications.
Journal ArticleDOI
Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial
Iacopo Olivotto,Artur Oreziak,Roberto Barriales-Villa,Theodore P. Abraham,Ahmad Masri,Pablo García-Pavía,Pablo García-Pavía,Sara Saberi,Neal K. Lakdawala,Matthew T. Wheeler,Anjali T. Owens,Milos Kubanek,Wojciech Wojakowski,Morten Kvistholm Jensen,Juan Ramón Gimeno-Blanes,Kia Afshar,Jonathan Myers,Jonathan Myers,Sheila M. Hegde,Scott D. Solomon,Amy J. Sehnert,David Zhang,Wanying Li,Mondira Bhattacharya,Jay M. Edelberg,Cynthia Burstein Waldman,Steven J. Lester,Andrew Wang,Carolyn Y. Ho,Daniel Jacoby,Jozef Bartunek,Antoine Bondue,Emeline Van Craenenbroeck,David Zemanek,Morten Søndergaard Jensen,Jens Mogensen,Jens Jakob Thune,Philippe Charron,Albert Hagège,Olivier Lairez,Jean Noël Trochu,Christoph Axthelm,Hans Dirk Duengen,Norbert Frey,Veselin Mitrovic,Michael Preusch,Jeanette Schulz-Menger,Tim Seidler,Michael Arad,Majdi Halabi,Amos Katz,Daniel Monakier,Offir Paz,Samuel Viskin,Donna R. Zwas,Hans-Peter Brunner-La Rocca,Michelle Michels,Dariusz Dudek,Zofia Oko-Sarnowska,Nuno Cardim,Helder Pereira,Pablo García Pavia,Juan Ramon Gimeno Blanes,Rafael Hidalgo Urbano,Luis Miguel Rincón Diaz,Perry M. Elliott,Zaheer Yousef,Theodore Abraham,Paulino Alvarez,Richard G. Bach,Richard C. Becker,Lubna Choudhury,David Fermin,John L. Jefferies,Christopher M. Kramer,Neal K. Lakdawala,Steven Lester,Ali J. Marian,Mathew S. Maurer,Sherif F. Nagueh,David R. Owens,Florian Rader,Mark V. Sherrid,Jamshid Shirani,John Symanski,Aslan T. Turer,Omar Wever-Pinzon,Timothy C. Wong,Mohamad H. Yamani +88 more
TL;DR: Treatment with mavacamten improved exercise capacity, LVOT obstruction, NYHA functional class, and health status in patients with obstructive hypertrophic cardiomyopathy and highlights the benefits of disease-specific treatment for this condition.
Journal ArticleDOI
Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction.
Céline Mias,Céline Mias,Olivier Lairez,Olivier Lairez,Elodie Trouche,Elodie Trouche,Jerome Roncalli,Denis Calise,Marie-Hélène Seguelas,Catherine Ordener,Marie-Dominique Piercecchi-Marti,Nathalie Augé,Anne Negre Salvayre,Philippe Bourin,Angelo Parini,Angelo Parini,Daniel Cussac,Daniel Cussac +17 more
TL;DR: MSCs modulate the phenotype of cardiac fibroblasts and their ability to degrade extracellular matrix and these properties open new perspectives for understanding the mechanisms of action of MSCs and anticipate their potential therapeutic or side effects.
Journal ArticleDOI
Post-Conditioning Reduces Infarct Size and Edema in Patients With ST-Segment Elevation Myocardial Infarction
Franck Thuny,Olivier Lairez,François Roubille,François Roubille,Nathan Mewton,Gilles Rioufol,Catherine Sportouch,Catherine Sportouch,Ingrid Sanchez,Cyrille Bergerot,Hélène Thibault,Hélène Thibault,Thien Tri Cung,Thien Tri Cung,Gérard Finet,Laurent Argaud,Didier Revel,Geneviève Derumeaux,Eric Bonnefoy-Cudraz,Meier Elbaz,Christophe Piot,Christophe Piot,Michel Ovize,Pierre Croisille,Pierre Croisille +24 more
TL;DR: It is demonstrated that post-conditioning reduced infarct size and edema in patients with reperfused STEMI, and this protective effect was confirmed after adjustment for the size of the area at risk.
Journal ArticleDOI
Long-Term Prognosis of Patients With Takotsubo Syndrome
Jelena-R. Ghadri,Ken Kato,Victoria L. Cammann,Sebastiano Gili,Stjepan Jurisic,Davide Di Vece,Alessandro Candreva,Katharina J. Ding,Jozef Micek,Konrad A. Szawan,Beatrice Bacchi,Rahel Bianchi,Rena A. Levinson,Manfred Wischnewsky,Burkhardt Seifert,Susanne A. Schlossbauer,Rodolfo Citro,Eduardo Bossone,Thomas Münzel,Maike Knorr,Susanne Heiner,Fabrizio D'Ascenzo,Jennifer Franke,Annahita Sarcon,L. Christian Napp,Miłosz Jaguszewski,Michel Noutsias,Hugo A. Katus,Christof Burgdorf,Heribert Schunkert,Holger Thiele,Johann Bauersachs,Carsten Tschöpe,Burkert Pieske,Lawrence Rajan,Guido Michels,Roman Pfister,Alessandro Cuneo,Claudius Jacobshagen,Gerd Hasenfuß,Mahir Karakas,Wolfgang Koenig,Wolfgang Rottbauer,Samir M. Said,Ruediger C. Braun-Dullaeus,Adrian P. Banning,Florim Cuculi,Richard Kobza,Thomas Fischer,Tuija Vasankari,K.E. Juhani Airaksinen,Grzegorz Opolski,Rafal Dworakowski,Philip MacCarthy,Christoph Kaiser,Stefan Osswald,Leonarda Galiuto,Filippo Crea,Wolfgang Dichtl,Klaus Empen,Stephan B. Felix,Clément Delmas,Olivier Lairez,Ibrahim El-Battrawy,Ibrahim Akin,Martin Borggrefe,John D. Horowitz,Martin Kozel,Petr Tousek,Petr Widimský,Ekaterina Gilyarova,Alexandra Shilova,Mikhail Gilyarov,David E. Winchester,Christian Ukena,Jeroen J. Bax,Abhiram Prasad,Michael Böhm,Thomas F. Lüscher,Frank Ruschitzka,Christian Templin +80 more
TL;DR: It is demonstrated that TTS can either be benign or a life-threating condition depending on the inciting stress factor, and a new classification based on triggers is proposed, which can serve as a clinical tool to predict short- and long-term outcomes of TTS.